Prevalence of antibodies to Hepatitis C virus among Nigerian patients with HIV infection

Inyama, Petrus Uchenna; Uneke, Chigozie Jesse; Anyanwu, Greg Ike; Njoku, Okonkwo Moses; Idoko, Julia Hauwa and Idoko, John Alechenu (2005) Prevalence of antibodies to Hepatitis C virus among Nigerian patients with HIV infection. Online Journal of Health and Allied Sciences, 4 (2). ISSN 0972-5997

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Nigeria belongs to the group of countries highly endemic for viral hepatitis; unfortunately information on the prevalence of hepatitis C amongst patients with HIV in Nigeria is very scarce. This hospital-based investigation was conducted at two major hospitals in Jos, Nigeria from June 2002 through May 2003. Serum samples from 490 confirmed HIV infected patients were assayed for the presence of antibodies to HCV, using a third generation enzyme linked immunosorbent assay. Twenty eight (5.7%; 95% CI 3.66-7.76%) of the patients had antibodies to HCV. The prevalence of HCV antibodies was higher among the males (7.5%; 95% CI 3.83-11.09%) than the females (4.5%; 95% CI 2.10-6.88%). Statistical analysis showed no significant difference (x2 = 1.917, df =1, p=0.05). Individuals of the age group 41-50 years had the highest prevalence of HCV antibodies (15.4%; 95% CI. 7.37-23.29%), followed by those of age group 31-40 years (7.4%; 95%, CI 3.70-11.20%). A significant difference was observed in the association between age and prevalence of HCV antibodies (x2 = 24.151, df = 4, p =0.05). Early diagnosis of HCV in people with HIV infection is advocated to reduce risk of HCV related advanced liver disease.

EPrint Type:Article
Uncontrolled Keywords:Hepatitis C virus, Human Immunodeficiency Virus, Nigeria, HCV Antibodies, Prevalence, Adult
Subjects:Immunologic and Biological Factors > Immunologic Factors > Antibodies
-Journal Repositories > Online Journal of Health and Allied Sciences
Immunologic Diseases > Immunologic Deficiency Syndromes > HIV Infections
Virus Diseases > Hepatitis, Viral, Human > Hepatitis C
Geographic Locations > Africa > Africa South of the Sahara > Africa, Western > Nigeria
ID Code:1023
Deposited By:Dr Srinivas Kakkilaya
Deposited On:26 September 2005

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