A two-year follow up of patients with quiescent pulmonary tuberculosis following a year of chemotherapy with an intermittent (twice weekly) regimen of isoniazid plus streptomycin or a daily regimen of isoniazid plus PAS

Nazareth, O.; Devaduta, S.; Evans, C.; Fox, Wallace; Janardhanam, B.; Menon, N.K.; Radhakrishnan, S.; Ramakrishnan, C.V.; Stott, H.; Tripathy, S.P. and Velu, S. (1967) A two-year follow up of patients with quiescent pulmonary tuberculosis following a year of chemotherapy with an intermittent (twice weekly) regimen of isoniazid plus streptomycin or a daily regimen of isoniazid plus PAS. Indian Journal of Tuberculosis, 24 (2). pp. 95-103.

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Abstract

In the main analysis of a year’s study of twice-weekly high dosage isoniazid plus streptomycin (SHTW) in comparison with a standard daily regimen of isoniazid plus PAS (PH) under domiciliary conditions, 66 SHTW and 53 PH patients had attained bacteriologically quiescent disease at one year. All the patients have now been folio wed-up over a two-year period. Of these, 66 SHTW and 52 PH patients had been allocated at random to treatment in the second year with isoniazid alone or with placebo. No patient was prescribed anti-tuberculosis drugs for the third year.

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