Dexamethasone suppression test in patients with obsessive compulsive disorder
Kuloglu, M.; Atmaca, M.; Gecici, O. and Tezcan, A.E. (2000) Dexamethasone suppression test in patients with obsessive compulsive disorder. Anatolian Journal of Psychiatry (Anadolu Psikiyatri Dergisi), 1 (1). pp. 13-18. ISSN 1302-6631
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Objective: Studies about biological relationship between affective disorders and obsessive compulsive disorder (OCD) which is classified by DSM- IV as anxiety disorder have increased. In our study, it is aimed to determine the specifity and sensitivity of Dexamethasone Suppression Test (DST) accepted as sensitive and spesific test in depressive disorders, in patients diagnosed OCD. Method: The sample consisted of 34 patients (24 females, 10 males) who had applied to Psychiatry Department of Fırat University Medical Faculty as inpatients or outpatients and diagnosed as OCD according to DSM- IV between November 1998-April 1999. Hamilton Depression Rating Scale (HRSD), Yale-Brown Obsessive Compulsive Scale (Y-BOCS), semistructured clinical information form and DST were performed to patients. Results: Of patients, 15 had comorbid moderate and severe depressive disorder. While it was determined DST nonsuppression in 11 (73.3 %) of patients with depressive pathology; none of 23 patients OCD alone exhibited nonsuppression. There was no association between severity of OCD and DST nonsuppression. Conclusion: Finally, our study supports the opinion that OCD may be a heterogenous subtype including some biological indicators of anxiety and affective disorders.
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