Atrial fibrillation and hyperthyroidism

Jayaprasad, N. and Johnson, Francis (2005) Atrial fibrillation and hyperthyroidism. Indian Pacing and Electrophysiology Journal, 5 (4). pp. 305-311. ISSN 0972-6292

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Abstract

Atrial fibrillation occurs in 10 – 15% of patients with hyperthyroidism. Low serum thyrotropin concentration is an independent risk factor for atrial fibrillation. Thyroid hormone contributes to arrythmogenic activity by altering the electrophysiological characteristics of atrial myocytes by shortening the action potential duration, enhancing automaticity and triggered activity in the pulmonary vein cardio myocytes. Hyperthyroidism results in excess mortality from increased incidence of circulatory diseases and dysrhythmias. Incidence of cerebral embolism is more in hyperthyroid patients with atrial fibrillation, especially in the elderly and anti-coagulation is indicated in them. Treatment of hyperthyroidism results in conversion to sinus rhythm in up to two-third of patients. Beta-blockers reduce left ventricular hypertrophy and atrial and ventricular arrhythmias in patients with hyperthyroidism. Treatment of sub clinical hyperthyroidism is controversial. Optimizing dose of thyroxine treatment in those with replacement therapy and beta-blockers is useful in exogenous subclinical hyperthyroidism.

EPrint Type:Article
Uncontrolled Keywords:Atrial fibrillation; Hyperthyroidism; Embolism; Electrophysiological characteristics; Thyroxine
Subjects:Hormones, Hormone Substitutes, and Hormone Antagonists > Hormones > Thyroid Hormones
-Journal Repositories > Indian Pacing and Electrophysiology Journal
Amino Acids, Peptides, and Proteins > Amino Acids > Amino Acids, Cyclic
Cardiovascular Diseases > Heart Diseases > Arrhythmia > Atrial Fibrillation
Cardiovascular Diseases > Vascular Diseases > Embolism and Thrombosis
Pathological Conditions, Signs and Symptoms > Pathologic Processes > Arrhythmia
Physiological Processes > Electrophysiology
Endocrine Diseases > Thyroid Diseases > Hyperthyroidism
ID Code:1097
Deposited By:Indian Pacing and Electrophysiology Journal
Deposited On:22 October 2005

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