Some observation on atypical mycobacteria from tuberculous meningitis in children. Part II: studies on drug sensitivity, animal pathogenicity and serological inter-relationship

Joishy, K.N. and Sant, M.V. (1969) Some observation on atypical mycobacteria from tuberculous meningitis in children. Part II: studies on drug sensitivity, animal pathogenicity and serological inter-relationship. Indian Journal of Tuberculosis, 16 (4). pp. 118-124.

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Abstract

Twelve strains of rapid growers (Runyon Group IV) were isolated from a total of 100 samples of cerebro-spinal-fluid (C.S.F.); collected from the cases of tuberculosis meningitis in children. The drug sensitivity pattern, animal pathogenicity and serological relationship of these strains were studied in comparison with Mycobacterium phlei and the refeence Group IV strain (T-64) of atypical mycobacteria. All the C.S.F. isolates exhibited high resistance of SM and comparatively less resistance to PAS, INH, ETH, THIA and KM. Three strains were sensitive to KM. A few of these isolates brought about atypical changes in organs of guinea pigs and mice. Intracerebral inoculations of these strains also revealed atypical picture in the brain tissue of mice. No typical tuberculosis changes were observed throughout the experiment. Serological interrelationship existed between C.S.F. isolates, Mycobacterium tuberculosis H37Rv and the reference strain (T-64) of Groud IV atypical mycobacteria. These organisms were found to share some of the common antigens. Thus, the C.S F. isolates formed a sort of biological link between typical and atypical

EPrint Type:Article
Uncontrolled Keywords:Tuberculous Meningitis, Atypical Mycobacteria, Children, Mycobacterium phlei, Drug Sensitivity, Animal Pathogenesis, Serological Inter-relationship, Cerebrospinal Fluid
Subjects:Bacterial Infections and Mycoses > Bacterial Infections > Gram-Positive Bacterial Infections > Actinomycetales Infections > Mycobacterium Infections > Tuberculosis
Bacterial Infections and Mycoses > Bacterial Infections > Central Nervous System Bacterial Infections
Bacterial Infections and Mycoses > Central Nervous System Infections > Central Nervous System Bacterial Infections
Bacteria > Gram-Positive Bacteria > Actinobacteria > Actinomycetales > Mycobacteriaceae > Mycobacterium > Mycobacterium tuberculosis
Bacterial Infections and Mycoses > Bacterial Infections > Gram-Positive Bacterial Infections > Actinomycetales Infections > Mycobacterium Infections
Investigative Techniques > Animal Experimentation
Health Occupations > Medicine > Epidemiology
Fluids and Secretions > Body Fluids
Health Occupations > Serology
Immunologic Diseases > Hypersensitivity > Drug Hypersensitivity
Animals > Chordata > Vertebrates > Mammals > Rodentia > Guinea Pigs
-Journal Repositories > Indian Journal of Tuberculosis
ID Code:1147
Deposited By:Mrs Naina Pandita
Deposited On:10 January 2006

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