Some observation on atypical mycobacteria from tuberculous meningitis in children. Part II: studies on drug sensitivity, animal pathogenicity and serological inter-relationship
Joishy, K.N. and Sant, M.V. (1969) Some observation on atypical mycobacteria from tuberculous meningitis in children. Part II: studies on drug sensitivity, animal pathogenicity and serological inter-relationship. Indian Journal of Tuberculosis, 16 (4). pp. 118-124.
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Twelve strains of rapid growers (Runyon Group IV) were isolated from a total of 100 samples of cerebro-spinal-fluid (C.S.F.); collected from the cases of tuberculosis meningitis in children. The drug sensitivity pattern, animal pathogenicity and serological relationship of these strains were studied in comparison with Mycobacterium phlei and the refeence Group IV strain (T-64) of atypical mycobacteria. All the C.S.F. isolates exhibited high resistance of SM and comparatively less resistance to PAS, INH, ETH, THIA and KM. Three strains were sensitive to KM. A few of these isolates brought about atypical changes in organs of guinea pigs and mice. Intracerebral inoculations of these strains also revealed atypical picture in the brain tissue of mice. No typical tuberculosis changes were observed throughout the experiment. Serological interrelationship existed between C.S.F. isolates, Mycobacterium tuberculosis H37Rv and the reference strain (T-64) of Groud IV atypical mycobacteria. These organisms were found to share some of the common antigens. Thus, the C.S F. isolates formed a sort of biological link between typical and atypical
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