Effect of lithium on acetylcholine esterase activity, and isozyme pattern in developing chick brain

Gouri, Anahita; Sathe, Kinneri; Ramachandran, Hema and Rajadhyaksha, Medha (2004) Effect of lithium on acetylcholine esterase activity, and isozyme pattern in developing chick brain. In: 27th All India Cell Biology Conference & International Symposium, 07 - 10 Jan 2004, Pune, India.

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Abstract

Acetylcholine Esterase is an enzyme, which hydrolyses acetylcholine and is used as a marker for cholinergic neural function. It is known to be involved in synaptogenesis. While on one hand it is known to be a marker for the developing chick brain it is also implicated in neurodegenerative diseases. In vertebrates the protein is synthesized by a single gene and undergoes alternative splicing to give 6-8 isoforms. Isozyme patterns of acetylcholine esterase have been suggested to be useful prognostic markers of neuronal degeneration. Lithium a well-known teratogen is known to induce apoptosis in the developing chick brain. Understanding the dynamics of acetylcholine esterase isoform pattern in lithium induced neural tissue damage would help elucidating the role of these isoforms in frank neurodegenerative diseases. We have therefore studied activity and isozyme pattern of acetylcholine esterase in lithium treated and control 7 day old developing chick brain and report the same.

EPrint Type:Conference or Workshop Item (Poster)
Additional Information:Presented a poster on the research work at the “XXVII All India Cell Biology Conference” held in January 2004 at the University of Pune and also gave a platform presentation at the “ Joint International Neuroscience Conference” held in May 2004, at the university of Hyderabad. Was honoured with the ‘D.M Kar - Young scientist 2004 award’. This project also received the 'Lady Tata Memorial Trust’ scholarship.
Uncontrolled Keywords:Lithium Acetylcholinesterase
Subjects:Neurotransmitters and Neurotransmitter Agents > Neurotransmitter Agents > Cholinergic Agents
ID Code:1183
Deposited By:Ms Anahita Gouri
Deposited On:21 December 2005

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