Biological pacemakers

Rajesh, G. and Francis, Johnson (2006) Biological pacemakers. Indian Pacing and Electrophysiology Journal, 6 (1). pp. 1-5. ISSN 0972-6292

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Abstract

Genetically engineered pacemakers could be a possible alternative to implantable electronic devices for the treatment of bradyarrhythmias. The strategies include upregulation of beta adrenergic receptors, conversion of myocytes into pacemaker cells and stem cell therapy. Pacemaker activity in adult ventricular myocytes is normally repressed by the inward rectifier potassium current (IK1). The IK1 current is encoded by the Kir2 gene family. Use of a negative construct that suppresses current when expressed with wild-type Kir2.1 is an experimental approach for genesis of genetic pacemaker. hyperpolarisation activated cyclic nucleotide gated (HCN) channels which generate If current, the pacemaker current of heart can be delivered to heart by using stem cell therapy approach and viral vectors. The unresolved issues include longevity and stability of pacemaker genes, limitations involved in adenoviral and stem cell therapy and creation of genetic pacemakers which can compete with the electronic units.

EPrint Type:Article
Uncontrolled Keywords:Gene therapy, Pacemaker current, HCN channels.
Subjects:Circulatory and Respiratory Physiology > Cardiovascular Physiology > Cardiovascular Physiologic Phenomena > Hemodynamic Phenomena > Heart Rate
Therapeutics > Biological Therapy > Gene Therapy
Physiological Processes > Chronobiology
-Journal Repositories > Indian Pacing and Electrophysiology Journal
Pathological Conditions, Signs and Symptoms > Pathologic Processes > Arrhythmia
ID Code:1233
Deposited By:Indian Pacing and Electrophysiology Journal
Deposited On:30 December 2005

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