Comparative trial of three regimens in the treatment of pulmonary tuberculosis
Chatterji, J.C.; Sen, S.K.; Mozumdar, S.C.; Basu, S.K.; Chakraborty, A.K.; Rao, Subba; Kapoor, M.L. and Chaterji, A.K. (1970) Comparative trial of three regimens in the treatment of pulmonary tuberculosis. Indian Journal of Tuberculosis, 17 (1). pp. 8-17.
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A controlled trial of three regimens viz. INH and PAS, bi-weekly streptomycin and high dose INH with 6 mg pyridoxine, andt INH and thiacetazone after initial treatment with streptomycin, INH and PAS for 3 months, was carried out, 139 out of 149 cases com. pleted 12 months of treatment. There was no significant difference in the effectiveness of the three regimens, Thiacetazone and INH combination more toxic and there was no toxicity to INH and streptomycin in the bi-weekly regimen. No patient in the thiacetazone schedule nor in any other schedule complained of any side effect. Five patients were taken off trial due to jaundice or hepatitis or persistently high SGOT/ SGPT. Four patients, who were absent fro pa the hospital for considerable periods, were not re-admitted into the trial and one patient had to be discharged from the hospital for adminis- trative reasons. Streptomycin toxicity and hypersensitivity to antituberculous drugs were negligible and all occurred during the first 3 months.
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