A double-blind study to determine the maximum tolerated dose of ethionamide, when administered twice-weekly to patients with pulmonary tuberculosis

Devadatta, S; Menon, N.K.; Nazareth, O.; Radhakrishna, S.; Ramakrishna, C.V.; Somasundaram, P.R.; Usha, S.P. and Veld, S. (1970) A double-blind study to determine the maximum tolerated dose of ethionamide, when administered twice-weekly to patients with pulmonary tuberculosis. Indian Journal of Tuberculosis, 17 (4). pp. 150-154.

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Abstract

A ‘double-blind’ study was undertaken to determine the maximum dose of ethionamide that could be tolerated for two weeks, when administered twice-weekly together with isonia- zid plus PAS. Of 27 patients, 10 (37 per cent) tolerated the highest planned dose of 1.5 g..;.on the other hand, nine (33 per cent) could not tolerate even 1.0 g.

EPrint Type:Article
Uncontrolled Keywords:Ethionamide, Pulmonary Tuberculosis, Double-Blind Study, Patients, Maximum Dose
Subjects:Heterocyclic Compounds > Acids, Heterocyclic > Isonicotinic Acids
Investigative Techniques > Drug Administration Schedule
Persons > Patients
Respiratory Tract Diseases > Lung Diseases > Tuberculosis, Pulmonary
-Journal Repositories > Indian Journal of Tuberculosis
Respiratory Tract Diseases > Respiratory Tract Infections > Tuberculosis, Pulmonary
ID Code:1245
Deposited By:Mrs Naina Pandita
Deposited On:28 February 2006

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