Susceptibility of conjunctival bacterial pathogens to fluoroquinolones: a comparative study of ciprofloxacin, norfloxacin and of loxacin

Idu, F.K. and Odjimogho, S.E. (2003) Susceptibility of conjunctival bacterial pathogens to fluoroquinolones: a comparative study of ciprofloxacin, norfloxacin and of loxacin. Online Journal of Health and Allied Sciences, 2 (3). ISSN 0972-5997

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Abstract

In order to determine the most common bacteria implicated in conjunctivitis, and the effectiveness of the antibiotic Fluoroquinolone for its treatment, a total of 50 subjects (100 ) eyes, between the ages of 1-30 years with mean age of 16.94 ± 8.06 years with infected eyes, were examined at the Lagos State University Teaching Hospital, Nigeria (LASUTH). Conjunctival swabs were collected and cultured in the laboratory to isolate the pathogens responsible for the infection. Sensitivity and antibiotic suscepticibility tests were carried out with discs impregnated with 0.3% concentration of ophthalmic topical solutions of chibroxin (Norfloxacin), ciloxan (Ciprofloxacin), and ocuflox (Ofloxacin), to ascertain the most sensitive of the three drugs. The results showed that the implicated bacteria in order of decreasing frequency were Staphylococcus aureus (34%), followed by Streptococcus pneumoniae (22%), Pseudomonas aeruginosa (14%), Klebsiella pneumoniae (12%), Hemophilus influenzae (9%), Escherichia coli (9%). All the isolated organisms were highly sensitive to the three drugs. However, a one way analysis of variance (ANOVA) showed a significant difference in the sensitivity of the three drugs (p< 0.05). ANOVA Post Hoc located Ciprofloxacin as the source of the significance. In conclusion therefore, Ciprofloxacin is the most sensitive of the three drugs and, hence should be the first choice of the fluoroquinolones for the treatment of bacterial conjunctivitis.

EPrint Type:Article
Uncontrolled Keywords:Conjunctivitis, Fluoroquinolones. Lagos, Swabs, Staphylococcus aureus, Streptococcus pneumoniae, Pseudomonas aeruginosa, Klebsiella pneumoniae, Hemophilus influenzae, Escherichia coli, Ciprofloxacin
Subjects:Heterocyclic Compounds > Heterocyclic Compounds, 2-Ring > Quinolines > Quinolones > Fluoroquinolones > Ciprofloxacin
Eye Diseases > Eye Infections > Eye Infections, Bacterial
-Journal Repositories > Online Journal of Health and Allied Sciences
Heterocyclic Compounds > Heterocyclic Compounds, 2-Ring > Quinolines > Quinolones > Fluoroquinolones
Heterocyclic Compounds > Heterocyclic Compounds, 2-Ring > Quinolines > Quinolones > Fluoroquinolones > Norfloxacin
ID Code:1303
Deposited By:Dr Srinivas Kakkilaya
Deposited On:25 January 2006

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