Risk factors for invasive epithelial ovarian cancer by histologic subtype

Quirk, Jeffrey T.; Natarajan, Nachimuthu; Mettlin, Curtis J.; Moysich, Kirsten B. and Swede, Helen (2004) Risk factors for invasive epithelial ovarian cancer by histologic subtype. Online Journal of Health and Allied Sciences, 3 (3). ISSN 0972-5997

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Abstract

It is unclear whether the different histologic subtypes of epithelial ovarian carcinoma have different risk factors. We investigated the relationships between selected epidemiologic variables (i.e., parity, family history of ovarian cancer, oral contraceptive use, a history of tubal ligation and noncontraceptive estrogen use) and the major histologic subtypes of epithelial ovarian cancer in a hospital-based case-control study of adult women at Roswell Park Cancer Institute in Buffalo, NY, USA. Multivariate unconditional logistic regression models were used for statistical analysis. We observed a pattern of increased risk associated with family history and a pattern of risk reduction associated with parity, noncontraceptive estrogen use and tubal ligation across all histologic subtype groups. However, we did not observe a consistent pattern of risk associated with oral contraceptive use. These results provide some additional support for the hypothesis that the effects of various ovarian cancer risk factors may differ according to the histologic subtype.

EPrint Type:Article
Uncontrolled Keywords:Epithelial ovarian cancer, Histology, Epidemiology, Case-control study
Subjects:Endocrine Diseases > Endocrine Gland Neoplasms > Ovarian Neoplasms
-Journal Repositories > Online Journal of Health and Allied Sciences
Neoplasms > Neoplasms by Site > Endocrine Gland Neoplasms > Ovarian Neoplasms
Neoplasms > Neoplasms by Site > Pelvic Neoplasms
Health Occupations > Medicine > Epidemiology
Neoplasms > Neoplasms by Histologic Type
ID Code:1316
Deposited By:Dr Srinivas Kakkilaya
Deposited On:30 January 2006

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