Assessment of rate of inactivation of isoniazid by the sulphadimidine acetylation test
Krishnaswami, K.V. and Jagadambal, K. (1973) Assessment of rate of inactivation of isoniazid by the sulphadimidine acetylation test. Indian Journal of Tuberculosis, 20 (3). pp. 120-123.
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Sulphadimidine acetylation test was carried out on 105 subjects for classification as rapid and slow inactivators. The test is simple, easy to perform and the results could be made available the same day. The patients may be classified as slow inaclivators if the preparation of acetylated sulphadimidine is 78% or less in urine at 5-6 hours and 41% or less in plasma at 6 hours. Among the subjects tested 57% were slow inactivators of isoniazid and 43% rapid inactivators of isoniazid.
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