Assessment of rate of inactivation of isoniazid by the sulphadimidine acetylation test

Krishnaswami, K.V. and Jagadambal, K. (1973) Assessment of rate of inactivation of isoniazid by the sulphadimidine acetylation test. Indian Journal of Tuberculosis, 20 (3). pp. 120-123.

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Abstract

Sulphadimidine acetylation test was carried out on 105 subjects for classification as rapid and slow inactivators. The test is simple, easy to perform and the results could be made available the same day. The patients may be classified as slow inaclivators if the preparation of acetylated sulphadimidine is 78% or less in urine at 5-6 hours and 41% or less in plasma at 6 hours. Among the subjects tested 57% were slow inactivators of isoniazid and 43% rapid inactivators of isoniazid.

EPrint Type:Article
Uncontrolled Keywords:Isoniazid Inactivation, Sulphadimidine Acetylation Test, Urine, Plasma
Subjects:Organic Chemicals > Amides > Sulfonamides
Organic Chemicals > Hydrazines > Isoniazid
Fluids and Secretions > Body Fluids > Urine
Biochemical Phenomena, Metabolism, and Nutrition > Metabolism
Investigative Techniques > Clinical Laboratory Techniques
-Journal Repositories > Indian Journal of Tuberculosis
ID Code:1479
Deposited By:Mrs Naina Pandita
Deposited On:04 May 2006

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