Ventricular tachycardia in the absence of structural heart disease

Srivathsan, Komandoor; Lester, Steven J.; Appleton, Christopher P.; Scott, Luis R. P. and Munger, Thomas M. (2005) Ventricular tachycardia in the absence of structural heart disease. Indian Pacing and Electrophysiology Journal, 5 (2). pp. 106-121. ISSN 0972-6292

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Abstract

In up to 10% of patients who present with ventricular tachycardia (VT), obvious structural heart disease is not identified. In such patients, causes of ventricular arrhythmia include right ventricular outflow tract (RVOT) VT, extrasystoles, idiopathic left ventricular tachycardia (ILVT), idiopathic propranolol-sensitive VT (IPVT), catecholaminergic polymorphic VT (CPVT), Brugada syndrome, and long QT syndrome (LQTS). RVOT VT, ILVT, and IPVT are referred to as idiopathic VT and generally do not have a familial basis. RVOT VT and ILVT are monomorphic, whereas IPVT may be monomorphic or polymorphic. The idiopathic VTs are classified by the ventricle of origin, the response to pharmacologic agents, catecholamine dependence, and the specific morphologic features of the arrhythmia. CPVT, Brugada syndrome, and LQTS are inherited ion channelopathies. CPVT may present as bidirectional VT, polymorphic VT, or catecholaminergic ventricular fibrillation. Syncope and sudden death in Brugada syndrome are usually due to polymorphic VT. The characteristic arrhythmia of LQTS is torsades de pointes. Overall, patients with idiopathic VT have a better prognosis than do patients with ventricular arrhythmias and structural heart disease. Initial treatment approach is pharmacologic and radiofrequency ablation is curative in most patients. However, radiofrequency ablation is not useful in the management of inherited ion channelopathies. Prognosis for patients with VT secondary to ion channelopathies is variable. High-risk patients (recurrent syncope and sudden cardiac death survivors) with inherited ion channelopathies benefit from implantable cardioverter-defibrillator placement. This paper reviews the mechanism, clinical presentation, and management of VT in the absence of structural heart disease.

EPrint Type:Article
Uncontrolled Keywords:Ventricular tachycardia; Structurally normal heart
Subjects:Cardiovascular Diseases > Heart Diseases > Arrhythmia > Tachycardia
-Journal Repositories > Indian Pacing and Electrophysiology Journal
Cardiovascular Diseases > Heart Diseases > Arrhythmia
Cardiovascular Diseases > Heart Diseases
ID Code:149
Deposited By:Indian Pacing and Electrophysiology Journal
Deposited On:03 July 2005

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