Comparative studies of cultural and histopathological aspects of experimental H37RV infection in guineapigs
Ganguly, N.K. and Chitkara, N.L. (1975) Comparative studies of cultural and histopathological aspects of experimental H37RV infection in guineapigs. Indian Journal of Tuberculosis, 22 (2). pp. 76-80.
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Sixty three tuberculin tested guineapigs were inoculated 1 mg. moist weight of H37Rv strain of Mycobact. tuberculosis and were sacrificed from 2 hours to 33 days at regularly spaced time intervals. The experiments were carried out in five sets to get as much reproducibility of results as possible. The original lymph nodes and spleen were studied for histopathology and Ziehl Neelsen’s staining of sections and was compared with AFB staining and culture of organ homo-genates. It was found that bacteriological methods could pick up an infected organ from 2 hours.
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