Liver functions during pyrazinamide therapy
Kamal, N.; Mukerjee, P.K.; Kishore, K.; Kumar, S. and Khanna, B.K. (1976) Liver functions during pyrazinamide therapy. Indian Journal of Tuberculosis, 23 (1). pp. 14-18.
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69 proved cases of pulmonary tuberculosis were studied for 6 months. They were getting pyrazinamide 30 mg/kg of body weight in the daily and biweekly regimen groups, respectively. On initiation of the therapy and after every one month serum pyrazinamide concentrations, SGPT, SGOT and serum alkaline phosphatase of all the patients of both groups were estimated. It was concluded that rise in the levels of SGPT, SGOT and serum alkaline phosphatase, during therapeutic administration of pyrazina- mide did not imply impending hepatic damage (during an observation period of 6 months). The rise in the level of these enzymes paralleled the rise in the level of serum pyrazinamide.
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