Comparison of insulin resistance by indirect methods - HOMA, QUICKI and McAuley - with fasting insulin in patients with type 2 diabetes in Galle, Sri Lanka: a pilot study

Hettihewa, Lukshmy M.; Palangasinghe, Shalika; Jayasinghe, Sudheera S.; Gunasekara, Sudari W. and Weerarathna, Thilak P. (2006) Comparison of insulin resistance by indirect methods - HOMA, QUICKI and McAuley - with fasting insulin in patients with type 2 diabetes in Galle, Sri Lanka: a pilot study. Online Journal of Health And Allied Sciences, 5 (1). pp. 1-8. ISSN 0972-5997

Full text available as:

PDF - Requires Adobe Acrobat Reader or other PDF viewer.
796 Kb

Abstract

Background: To investigate importance of fasting insulin (FI) as a diagnostic test for insulin resistance (IR) and to compare with other standard methods McAuley (McA), HOMA and QUICKI indices in Diabetes Mellitus (DM). Method: 42 diabetic patients who have been already diagnosed were used in our study. They were investigated for fasting blood glucose (FBS), FI, LDL, Triglycerides (TG), total cholesterol (TC) and HDL levels. IR was calculated by McA, HOMA, QUICKI indices and by FI. Results: 81% of patients were insulin resistant by McA and FI in our study group. 93% were detected as insulin resistant by HOMA and QUICKI. IR by FI was further compared with HOMA and QUICKI and 81% of patients were found to be insulin resistant by FI, HOMA and QUICKI. Results showed that there was a significant correlation between FI and McA in expressing IR in our study group (p <0.01, r = -0.849). Further, FI had a statistically significant correlation with HOMA and QUICKI indices (p <0.01, r = 0.906 and p <0.01 r = -0.822 respectively). Conclusion: FI measurement alone in diabetic patients has detected IR in 81% of patients, similar to the other standard methods (McA; 81%, HOMA and QUICKI; 93%). We further identified that FI as a diagnostic test of IR had substantial correlation with McA. Our results recommend further studies to see the possibility of taking fasting insulin to determine IR in type 2 diabetic population

EPrint Type:Article
Uncontrolled Keywords:Insulin resistance, McAuley index, HOMA index, QUICKI index, Fasting Insulin, Type 2 Diabetes Mellitus
Subjects:Endocrine Diseases > Diabetes Mellitus > Diabetes Mellitus, Type II
Nutritional and Metabolic Diseases > Metabolic Diseases > Glucose Metabolism Disorders > Hyperinsulinism > Insulin Resistance
Investigative Techniques > Clinical Laboratory Techniques
-Journal Repositories > Online Journal of Health and Allied Sciences
Diagnosis > Laboratory Techniques and Procedures
ID Code:1670
Deposited By:Dr Srinivas Kakkilaya
Deposited On:17 July 2006

Archive Staff Only: edit this record