A randomised comparison of oral and vaginal misoprostol for medical management of first trimester missed abortion

., Rita; Gupta, Shashi and Kumar, Surender (2006) A randomised comparison of oral and vaginal misoprostol for medical management of first trimester missed abortion. JK Science Journal of Medical Education, 8 (1). pp. 35-38. ISSN 0972-1177

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Abstract

The present study was done to compare the safety and efficacy of misoprostol administered orally and vaginally for medical management of first trimester missed abortion. 100 women with diagnosed missed abortion were taken for this prospective study. Group A comprised of 50 women who were given oral misoprostol and another 50 in-group B were administered vaginal misoprostol. Clinical outcome, time taken for expulsion, number of doses required, side effects and cervical permeability were compared in two groups. Eighty percent in group B and 36% in group A had successful clinical outcome (p=0.000008). 16.6% in group A and 22.5% in group B expelled with a single dose while 50% and 77.5% expelled with complete schedule. Mean duration of expulsion was significantly higher in group A as compared to group B. Nearly ninety percent of women in both groups had good cervical permeability. Side effects were more common in group A. Hence vaginal misoprostol was found to be more effective and safer as compared to oral misoprostol.

EPrint Type:Article
Additional Information:ORIGINAL ARTICLE 8(1),2006, JK SCIENCE
Uncontrolled Keywords:Misoprostol, First Trimester, Missed Abortion, Vagina, Clinical Outcome
Subjects:Reproductive and Urinary Physiology > Reproduction > Pregnancy > Pregnancy Outcome
Anti-Inflammatory Agents, Antirheumatic Agents, and Inflammation Mediators > Inflammation Mediators > Prostaglandins, Synthetic
Female Genital Diseases and Pregnancy Complications > Pregnancy Complications > Abortion, Spontaneous
Urogenital System > Genitalia
ID Code:1721
Deposited By:JK Science: Journal of Medical Education and Research
Deposited On:07 August 2006

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