Predictors of response to pharmacotherapy in obsessive compulsive disorder
Uguz, F. (2006) Predictors of response to pharmacotherapy in obsessive compulsive disorder. Anatolian Journal of Psychiatry (Anadolu Psikiyatri Dergisi), 7 (1). pp. 5-12.
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Objective: In this study, we aimed to investigate associations between response to pharmacotherapy in obsessive compulsive disorder (OCD) and sociodemographic and clinical characteristics, comorbid axis I and II disorders. Methods: Fifty patients with OCD diagnosed according to DSM-IV criteria were included in the study. After initial clinical evaluation with Structured Clinical Interview for DSM-IV/Clinical Version (SCID-I/CV), Struc-tured Clinical Interview for DSM-III-R Personality Disorders (SCID-II) and Yale-Brown Obsessive-Compulsive Scale (Y-BOCS), all patients underwent a 12-week treatment with flexible-dose fluvoxamine, sertraline or paroxetine. Response to treatment was defined as a decrease at least a 35% on Y-BOCS total score at the end of 12-week treatment. Results: Forty-three patients completed the study. Nonresponders had a significantly higher frequency of any comorbid axis I disorder, and higher symptom severity and insight scores on Y-BOCS. When these variables were entered into logistic regression analyses, it was confirmed that a high Y-BOCS total score to be the independent predictor of poor response to pharmacotherapy. Conclusion: Our findings suggested that more severe obsessive-compulsive symptoms negatively influence response to pharmacotherapy and inde-pendent predictor of poor treatment response in patients with OCD.
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