Probiotics in humans: evidence based reviewHarish K, Harish K and Varghese T, Varghese T (2006) Probiotics in humans: evidence based review. Calicut Medical Journal, 4 (4). e3. Full text available as:
AbstractProbiotics are live microbial food supplements or components of bacteria, which have been shown to have beneficial effects on human health. They are perceived to exert such effects by changing the composition of the gut microbiota. Several probiotic preparations seem to have promise in prevention or treatment of various conditions. There currently exists good evidence for the therapeutic use of probiotics in infectious diarrhea in children, recurrent Clostridium difficile induced infections and postoperative pouchitis. The possible benefit in other gastrointestinal infections, prevention of postoperative bacterial translocation, irritable bowel syndrome and inflammatory bowel disease continues to emerge. This review addresses the concept of probiotics and evidence from human clinical trials regarding the possible uses of probiotics in clinical practice.
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