Isoniazid phenotyping of pulmonary tuberculosis in patients by sulphadimidine acetylation test in urine and in blood
Sinha, C.P.; Sinha, S. and Sinha, K.P. (1978) Isoniazid phenotyping of pulmonary tuberculosis in patients by sulphadimidine acetylation test in urine and in blood. Indian Journal of Tuberculosis, 25 (3). pp. 136-140.
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Samples of plasma and urine were obtained from 60 patients of pulmonary tuberculosis after oral administration of sulphadimidine in doses of 44 mg/kg. body weight. Free and total sulphadimidine concentration was estimated in urine and blood. The patients were classified as slow acetylators of Isoniazid if the proportion of acetylated sulphadimidine (total minus free) was (a) upto or less than 35 % in blood and (b) upto or less than 65 % in urine. 58 % were slow acetylators and 42 % rapid acetylators by blood estimation. 60 % were slow acetylators and 40 % rapid by urine estimation. The correlation co-efficient ‘r’ was worked out and found to be 0.82 which show high degree of correlation. The percentage of acetylation of sulphadimidine in serum & urine was equally efficient for phenotyping of rapid, slow acetyla-tors.
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