A case of progressive, fatal bone marrow depression associated with first line anti-tubercular dug therapy

Sarvesha, Nanda and Prasad, S.N. (1978) A case of progressive, fatal bone marrow depression associated with first line anti-tubercular dug therapy. Indian Journal of Tuberculosis, 25 (3). pp. 158-160.

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Abstract

This is a report of a fatal case of acute progressive bone-marrow depression associated with first-line anti-tubercular drug therapy, which we believe to be the first of its kind so far reported in India. But in as much as such catastrophes were observed in western countries to the extent that thiacetazone has almost disappeared from use there, we pose the question whether the ‘Indian marrow’ is relatively insusceptible to this drug, or whether such phenomena have so far escaped notice—as would be entirely possible if such a patient, in an outdoor clinic, simply failed to return for periodic check-ups (cf., Khanna & Singh, 1973). In any case, our observations suggest we should keep our mind open to possible severe bone-marrow depression, when using thiacetazone.

EPrint Type:Article
Uncontrolled Keywords:Bone-marrow Depression, Anti-tubercular Drug Therapy, Pulmonary Tuberculosis, Thiacetazone
Subjects:Organic Chemicals > Sulfur Compounds > Thiosemicarbazones
Hemic and Lymphatic Diseases > Hematologic Diseases > Bone Marrow Diseases
Respiratory Tract Diseases > Lung Diseases > Tuberculosis, Pulmonary
-Journal Repositories > Indian Journal of Tuberculosis
Respiratory Tract Diseases > Respiratory Tract Infections > Tuberculosis, Pulmonary
ID Code:1886
Deposited By:Mrs Naina Pandita
Deposited On:06 December 2006

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