A case of progressive, fatal bone marrow depression associated with first line anti-tubercular dug therapy
Sarvesha, Nanda and Prasad, S.N. (1978) A case of progressive, fatal bone marrow depression associated with first line anti-tubercular dug therapy. Indian Journal of Tuberculosis, 25 (3). pp. 158-160.
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This is a report of a fatal case of acute progressive bone-marrow depression associated with first-line anti-tubercular drug therapy, which we believe to be the first of its kind so far reported in India. But in as much as such catastrophes were observed in western countries to the extent that thiacetazone has almost disappeared from use there, we pose the question whether the ‘Indian marrow’ is relatively insusceptible to this drug, or whether such phenomena have so far escaped notice—as would be entirely possible if such a patient, in an outdoor clinic, simply failed to return for periodic check-ups (cf., Khanna & Singh, 1973). In any case, our observations suggest we should keep our mind open to possible severe bone-marrow depression, when using thiacetazone.
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