Effect of aspirin in the control of hyperuricemia and arthralgia due to pyrazinamide (PZA) therapy
Natraja Iyer, K. and Srinavasan, P. (1978) Effect of aspirin in the control of hyperuricemia and arthralgia due to pyrazinamide (PZA) therapy. Indian Journal of Tuberculosis, 25 (4). pp. 198-199.
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45 patients on Pyrazinamide therapy were studied. All of them showed an increased serum uric acid level. Thirty of them had arthralgia of varying intensity affecting one or more joints. Radiography of the involved joints showed no abnormality in any patient. On withdrawal of PZA or addition of 1.8 gm aspirin daily, uric acid level returned to normal and arthraligia disappeared in 15 days.
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