Evolution of curative therapies for atrial fibrillation
Khasnis, Atul; Veerareddy, Srikar; Jongnarangsin, Krit; Ip, John H; Abela, George S and Thakur, Ranjan K (2004) Evolution of curative therapies for atrial fibrillation. Indian Pacing and Electrophysiology Journal, 4 (1). pp. 10-25. ISSN 0972-6292
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Atrial fibrillation (AF) is one of the most common arrhythmias seen in clinical practice. The incidence of AF increases with age and is seen in up to 8.9% of individuals greater than 80 years of age.1 Although many treatment modalities are available for AF, curative therapy has recently become possible for some patients with atrial fibrillaton. This is partly due to the complexity and incomplete understanding of this arrhythmia. Pharmacological therapies for the management of AF have many limitations such as side effects, cost, inconvenience, breakthrough arrhythmias, drug-drug interactions and continued need for anticoagulation. An improved understanding of the pathophysiology and electrophysiologic basis of AF coupled with the availability of better mapping techniques as well as advances in catheter technology offer promise for curative treatment. This article will briefly review the understanding of the mechanisms of AF and then the evolution of catheter techniques for control and elimination of AF.
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