Short-term chemotherapy of pulmonary tuberculosis: a controlled trial

Tuberculosis Research Centre, Bangalore (1980) Short-term chemotherapy of pulmonary tuberculosis: a controlled trial. Indian Journal of Tuberculosis, 27 (2). pp. 48-53.

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Abstract

Two short-term (20 weeks) chemotherapy regimens, one consisting of of INH, Streptomycin and Ethambutol and the other Pyrazinamide, INH, Streptomycin and Ethambutol were compared with a standard regimen of Streptomycin and INH Tor 8 weeks followed bv INH and Thiacetazone for 72 weeks. Two hundred and twenty seven patients in all were randomly allocated to the 3 regimens. Toxic reactions were negligible in all regimens. Patients in the trial regimens were hospitalized for the entire duration of chemotherapy viz. 20 weeks and patients in the standard regimen wore hospitalized only for the first 8 weeks. All patients took the drug with a high degree of regularity. Sputum conversion at the completion of treatment was nearly 100% in all 3 regimens. Radiological changes were also more or less similar. Patients were followed for a total period of 132 weeks. The rate of worsening in the follow up period up period was 16.4% in the Rifampicin regimen, 32.2% in the Pyrazinamide regimen and 11.2% in the control regimen. The observed rate of worsening was more amongst those with more extensive disease, cases with multiple cavities and those who took longer time to get converted initially although these differences did not attain statistical significance. Sputum conversion rate was fairly high even in patients with initial drug resistance.

EPrint Type:Article
Additional Information:The trial was planned and supervised and the report prepared by the Research Committee consisting of Dr. R. Viswanathan (Chairman), Dr. S. P. Pamra, Dr, H.B. Dingley and Or. M.M. Singh. Culture and sensitivity testing was carried out at the laboratory of the New Delhi Tuberculosis Centre under the supervision of J)r. V.K. Perumal. Statistical aspects of the study were looked alter by Shri G.P. Mathur, Statistician, New Delhi Tuberculosis Centre.
Uncontrolled Keywords:Streptomycin, INH, Ethambutol, Pyrazinamide, Rifampicin, Thiacetazone, Short Term Chemotherapy, Pulmonary Tuberculosis, Clinical Trial, Follow-up, Radiological Changes, Drug Resistance, Drug Combinations, Sputum
Subjects:Investigative Techniques > Evaluation Studies > Clinical Trials
Therapeutics > Drug Therapy
Chemical and Pharmacologic Phenomena > Drug Resistance
Organic Chemicals > Hydrazines > Isoniazid
Heterocyclic Compounds > Heterocyclic Compounds with 4 or More Rings > Rifamycins
Pharmaceutical Preparations > Drug Combinations
Chemical and Pharmacologic Phenomena > Drug Tolerance
Diagnosis > Diagnostic Techniques and Procedures > Diagnostic Imaging > Radiography
Organic Chemicals > Sulfur Compounds > Thiosemicarbazones
Fluids and Secretions > Bodily Secretions > Sputum
Disorders of Environmental Origin > Poisoning > Drug Toxicity
Organic Chemicals > Amines > Polyamines
Respiratory Tract Diseases > Respiratory Tract Infections > Tuberculosis, Pulmonary
Carbohydrates and Hypoglycemic Agents > Carbohydrates > Glycosides > Aminoglycosides > Streptomycin
Heterocyclic Compounds > Heterocyclic Compounds, 1-Ring > Pyrazines
Chemical and Pharmacologic Phenomena > Drug Design
Respiratory Tract Diseases > Lung Diseases > Tuberculosis, Pulmonary
-Journal Repositories > Indian Journal of Tuberculosis
ID Code:2124
Deposited By:Mrs Naina Pandita
Deposited On:15 May 2007

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