Short-term chemotherapy of pulmonary tuberculosis: a controlled trial
Tuberculosis Research Centre, Bangalore
Short-term chemotherapy of pulmonary tuberculosis: a controlled trial.
Indian Journal of Tuberculosis, 27 (2).
Full text available as:
Two short-term (20 weeks) chemotherapy regimens, one consisting of of INH,
Streptomycin and Ethambutol and the other Pyrazinamide, INH, Streptomycin and Ethambutol
were compared with a standard regimen of Streptomycin and INH Tor 8 weeks followed bv INH and
Thiacetazone for 72 weeks. Two hundred and twenty seven patients in all were randomly allocated to
the 3 regimens. Toxic reactions were negligible in all regimens. Patients in the trial regimens were
hospitalized for the entire duration of chemotherapy viz. 20 weeks and patients in the standard regimen
wore hospitalized only for the first 8 weeks. All patients took the drug with a high degree of regularity.
Sputum conversion at the completion of treatment was nearly 100% in all 3 regimens. Radiological
changes were also more or less similar. Patients were followed for a total period of 132 weeks. The rate
of worsening in the follow up period up period was 16.4% in the Rifampicin regimen, 32.2% in the
Pyrazinamide regimen and 11.2% in the control regimen. The observed rate of worsening was more
amongst those with more extensive disease, cases with multiple cavities and those who took longer
time to get converted initially although these differences did not attain statistical significance.
Sputum conversion rate was fairly high even in patients with initial drug resistance.
|Additional Information:||The trial was planned and supervised and the report prepared by the Research Committee consisting of Dr. R.
Viswanathan (Chairman), Dr. S. P. Pamra, Dr, H.B. Dingley and Or. M.M. Singh. Culture and sensitivity testing
was carried out at the laboratory of the New Delhi Tuberculosis Centre under the supervision of J)r. V.K. Perumal.
Statistical aspects of the study were looked alter by Shri G.P. Mathur, Statistician, New Delhi Tuberculosis Centre.|
|Uncontrolled Keywords:||Streptomycin, INH, Ethambutol, Pyrazinamide, Rifampicin,
Thiacetazone, Short Term Chemotherapy, Pulmonary Tuberculosis, Clinical Trial, Follow-up, Radiological Changes, Drug Resistance, Drug Combinations, Sputum|
|Subjects:||Investigative Techniques > Evaluation Studies > Clinical Trials|
Therapeutics > Drug Therapy
Chemical and Pharmacologic Phenomena > Drug Resistance
Organic Chemicals > Hydrazines > Isoniazid
Heterocyclic Compounds > Heterocyclic Compounds with 4 or More Rings > Rifamycins
Pharmaceutical Preparations > Drug Combinations
Chemical and Pharmacologic Phenomena > Drug Tolerance
Diagnosis > Diagnostic Techniques and Procedures > Diagnostic Imaging > Radiography
Organic Chemicals > Sulfur Compounds > Thiosemicarbazones
Fluids and Secretions > Bodily Secretions > Sputum
Disorders of Environmental Origin > Poisoning > Drug Toxicity
Organic Chemicals > Amines > Polyamines
Respiratory Tract Diseases > Respiratory Tract Infections > Tuberculosis, Pulmonary
Carbohydrates and Hypoglycemic Agents > Carbohydrates > Glycosides > Aminoglycosides > Streptomycin
Heterocyclic Compounds > Heterocyclic Compounds, 1-Ring > Pyrazines
Chemical and Pharmacologic Phenomena > Drug Design
Respiratory Tract Diseases > Lung Diseases > Tuberculosis, Pulmonary
-Journal Repositories > Indian Journal of Tuberculosis
|Deposited By:||Mrs Naina Pandita|
|Deposited On:||15 May 2007|
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