Correlates of hallucinations in schizophrenia: a cross‐cultural evaluation

Thomas, P.; Mathur, P.; Gottesman, I.I.; Nagpal, R.; Nimgaonkar, V.L. and Deshpande, S.N. (2007) Correlates of hallucinations in schizophrenia: a cross‐cultural evaluation. Schizophrenia Research. pp. 1-9.

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Introduction: Demographic, clinical and familial factors may plausibly influence the manifestation of hallucinations. It is unclear if the pattern of the effects is similar in different environmental/cultural settings. Aims: To evaluate factors associated with hallucination from a demographic, clinical and familial perspective in two distinct cultural settings. Methods: Patients with a clinical diagnosis of schizophrenia (SZ) or schizoaffective disorder (SZA) were diagnosed systematically using DSM IV criteria. Two independent samples were recruited in India and USA using identical inclusion/exclusion criteria and assessment procedures (n=1287 patients total; 807 Indian and 480 US participants). The association of key demographic and clinical factors with hallucinations of different modalities was examined. To evaluate the impact of familial factors, we separately analyzed correlations among affected sibling pairs (ASPs, n=136, Indian; n=77, US). Results: The prevalence of different modalities of hallucinations differed in the Indian and US samples, though the rank order of frequency was similar. The pattern of associations between selected variables and the risk of hallucinations was different across cultures, except for some correlations with indices of severity. No significant concordance was observed among the ASPs after correcting for multiple comparisons. Conclusions: The factors associated with hallucinations vary across environments. Our results are consistent with a multi‐factorial etiology of psychopathology, but re‐direct attention to endophenotypic features in the causal chain that precede the symptoms themselves. © 2007 Elsevier B.V. All rights reserved.

EPrint Type:Article
Uncontrolled Keywords:Schizophrenia; Schizoaffective disorder; Hallucination; Concordance; Genetic; Endophenotype; Cross‐cultural
Subjects:Genetic Processes > Heredity
Environment and Public Health > Public Health > Epidemiologic Measurements > Demography
Population Characteristics > Population
Population Characteristics > Demography
Geographic Locations > Asia > Asia, Western > India
Persons > Population Groups
Geographic Locations > Americas > North America > United States
Population Characteristics > Socioeconomic Factors
Behavior and Behavior Mechanisms > Neurobehavioral Manifestations
Nervous System Diseases > Neurologic Manifestations > Neurobehavioral Manifestations
Environment and Public Health > Environment
Mental Disorders > Schizophrenia and Disorders with Psychotic Features
Pathological Conditions, Signs and Symptoms > Signs and Symptoms
Social Sciences > Demography
Social Sciences > Sociology
Psychological Phenomena and Processes > Mental Health
ID Code:2139
Deposited By:Dr Triptish Bhatia
Deposited On:14 May 2007

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