Genetic susceptibility to tardive dyskinesia in chronic schizophrenia subjects: III. Lack of association of CYP3A4 and CYP2D6 gene polymorphisms
Tiwari, Arun K.; Deshpande, Smita N.; Rao, A.R.; Bhatia, Triptish; Lerer, Bernard; Nimgaonkar, Vishwajit L. and Thelma, B.K. (2005) Genetic susceptibility to tardive dyskinesia in chronic schizophrenia subjects: III. Lack of association of CYP3A4 and CYP2D6 gene polymorphisms. Schizophrenia Research, 75. pp. 21-26.
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Tardive dyskinesia is a severe debilitating movement disorder characterized by choreoathetotic movements developing in one-fifth of the patients with schizophrenia. In this study we have investigated the significance of CYP3A4*1B and CYP2D6*4 polymorphisms in TD susceptibility among chronic schizophrenia patients (n=335) from north India. Tardive dyskinesia was diagnosed in ~29% (96/335) of these patients. No significant association of either of the two SNPs with TD (CYP3A4*1B v2=0. 308, df=1, p=0.579; CYP2D6*4 v2=0.006, df=1, p=0.935) was observed. However a trend towards increased severity of TD in patients heterozygous for the CYP2D6*4 mutation was observed. D 2005 Elsevier B.V. All rights reserved.
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