Characterization of the Pasteurella multocida isolates by their outer membrane protein profile

Jain, Anshu; Roy, A.; Rank, D.N.; Joshi, C.G. and Purohit, J.H. (2005) Characterization of the Pasteurella multocida isolates by their outer membrane protein profile. Indian J. Compo Microbiol. Immunol. Infect. Dis., 26 (1). pp. 63-65.

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Abstract

Pasteurella multocida is an important primary and opportunistic pathogen as well as a commensal of the upper respiratory tract of various domestic and wild animals. However, in predisposed conditions it can cause a wide range of economically important diseases, including fowl cholera in poultry, haemorrhagic septicaemia in cattle and buffalo, atrophic rhinitis in swine and snuffles in rabbits. Prophylaxis plays a major role in controlling these diseases and many attempts have been made by different workers to develop effective vaccines using various form viz. alum precipitation, formalized and oil adjuvant of whole cell vaccines (Carter, 1967). In the present report attempts were made using capsules, lipopolysaccharides (LPS), and outer membrane protein components as vaccine (Confer, 1993). The outer membrane protein (OMP) of Gram negative bacteria has a role in disease processes as it acts at an interface between the host and pathogen (Lin et at., 2002). Outer membrane proteins (OMPs) of P. multocida plays significant role in the pathogenesis of pasteurellosis and have been identified as potent immunogens. Thus a variation in OMP profile among the isolates may help in epidemiological survey.

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