Thio-acetazone serum levels in North Indian patients
Khanna, B.K.; Khan, P.; Kumar, A. and Mukerji, P.K. (1981) Thio-acetazone serum levels in North Indian patients. Indian Journal of Tuberculosis, 28 (3). pp. 131-134.
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64 hospitalized patients of pulmonary tuberculosis of North Indian origin were administered thioacetazone in 3 doses along with other anti-tuberculosis drugs. Serum thioacetazone levels were found to be higher in those receiving higher dosages of thioacetazone though the rise in the serum levels was not proportional to the close administered. Assuming an arbitrary concentration of thioacetazone 0.5 ug/ml for determining the coverage, 2/3rd increase in the exposure was seen when the dose was increased from 150 mg. to 450 mg. Clinical and biochemical parameters to determine thioacetazone toxicity were found to be within normal limits. Minor gastrointestinal irritation, not necessitating the withdrawal of the drug was encountered in 4 patients on 450 mg. dosage of thic-acetazone.
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