Current developments in microvolt T-wave alternans

Sredniawa, Beata; Musialik-Lydka, Agata; Kowalczyk, Jacek and Kalarus, Zbigniew (2006) Current developments in microvolt T-wave alternans. Indian Pacing and Electrophysiology Journal, 6 (4). pp. 214-225. ISSN 0972-6292

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Microvolt T-wave alternans (MTWA), the beat-to-beat fluctuation in T wave amplitude and morphology, is closely linked to vulnerability to ventricular arrhythmias in various experimental and clinical conditions. Clinically, MTWA is most commonly measured using the spectral method, although non-spectral methods for its assessment from ambulatory electrocardiographical recordings also have been developed. Recent studies suggest that the quantitative assessment of TWA may also be clinically relevant. The standardization of the criteria for abnormal MTWA test still needs to be completed. The expansion of indications for implantable cardioverter-defibrillator (ICD) therapy following the positive results of the MADIT-II and SCD-HeFT trials might have unacceptable economic and medical consequences, and therefore new tests are needed to better discriminate patients who will and will not benefit from ICD implantation. A recent meta-analysis of MTWA studies revealed an overall positive predictive value for arrhythmic events of 19.3%, negative predictive value of 97.2%, and 3.77% univariate relative risk of arrhythmic events. The negative predictive value of MTWA in MADIT-II type patients has been reported to be 97.5%. The predictive value of the test varied significantly in different patient population. Current data support the use of MTWA testing for evaluation of patients with low ejection fraction who are considered for ICD implantation. The independence of the prognostic value of MTWA from other clinical and electrophysiological variables needs further confirmation.

EPrint Type:Article
Uncontrolled Keywords:Microvolt T wave Alternans, Implantable Cardioverter-Defibrillator, Ventricular Arrhythmias, Sudden Cardiac Death, Risk Stratification
Subjects:-Journal Repositories > Indian Pacing and Electrophysiology Journal
Diagnosis > Diagnostic Techniques and Procedures > Diagnostic Techniques, Cardiovascular > Heart Function Tests
Cardiovascular Diseases > Heart Diseases > Arrhythmia
Equipment and Supplies > Electrodes > Defibrillators > Defibrillators, Implantable
Therapeutics > Cardiac Pacing, Artificial
Pathological Conditions, Signs and Symptoms > Pathologic Processes > Arrhythmia
ID Code:2293
Deposited By:Indian Pacing and Electrophysiology Journal
Deposited On:03 September 2007

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