Anti-TB drug regimens: an approach through pharmacotherapeutic basis

Sen, P.K. and Chaterjee, R. (1981) Anti-TB drug regimens: an approach through pharmacotherapeutic basis. Indian Journal of Tuberculosis, 28 (3). pp. 191-199.

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Abstract

This study introduces the pharmacological basis of choice of drugs or drugs -regimens for adequate therapeutic action. Pharmacological parameters such as peak concentration (P.C.), peak hour, half-life and minimum inhibitory concentration (MIC) coverage of Isoniazid. Thiacetazonc and Pyraziriamide were estimated. Parameters for the other four important anti-tuberculous drugs i.e. Streptomycin, Rifampicin, Ethambutol and PAS are also considered. PC/MIC ratio may be considered a better and reasonable index for evaluation of drug action. Considering al 1 these data, suggestions have been made for drugs and combination of drugs for most effective action on pharmaco-therapeutic

EPrint Type:Article
Uncontrolled Keywords:Anti-TB Drugs, Drug Regimens, Pulmonary Tuberculosis, Pharmacology, Isoniazid, Thiacetazone, Pyraziriamide, Streptomycin, Rifampicin, Ethambutol, PAS
Subjects:Organic Chemicals > Hydrazines > Isoniazid
Organic Chemicals > Amines > Polyamines
Heterocyclic Compounds > Heterocyclic Compounds with 4 or More Rings > Rifamycins
Respiratory Tract Diseases > Respiratory Tract Infections > Tuberculosis, Pulmonary
Organic Chemicals > Carboxylic Acids > Hydroxy Acids > Hydroxybenzoic Acids > Salicylic Acids > Aminosalicylic Acids > p-Aminosalicylic Acid
Carbohydrates and Hypoglycemic Agents > Carbohydrates > Glycosides > Aminoglycosides > Streptomycin
Biological Sciences > Pharmacology
Investigative Techniques > Drug Administration Schedule
Heterocyclic Compounds > Heterocyclic Compounds, 1-Ring > Pyrazines
Chemical and Pharmacologic Phenomena > Drug Design
Organic Chemicals > Sulfur Compounds > Thiosemicarbazones
Respiratory Tract Diseases > Lung Diseases > Tuberculosis, Pulmonary
-Journal Repositories > Indian Journal of Tuberculosis
Health Occupations > Pharmacology
ID Code:2295
Deposited By:Mrs Naina Pandita
Deposited On:26 August 2007

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