Reduction in dose requirement of vecuronium bromide during BIS guided deep hypnosis produced By sevoflurane, isoflurane and propofol
Jain, Anil Kumar (2002) Reduction in dose requirement of vecuronium bromide during BIS guided deep hypnosis produced By sevoflurane, isoflurane and propofol. 50th National Conference of Indian Society of Anaesthesiologists Coimbatore 2002.
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Introduction: Potentiation of nondepolarizing muscle relaxants activity by volatile anesthetics usually results in either a prolongation in the duration of relaxant action or decrease in the dosage requirement of muscle relaxants. Most of the studies use 1 MAC anesthetic dose for observing effects on the action of the muscle relaxants. Deep hypnosis to blunt hemodynamic response to surgical stimulation is required in many situations. In our study decreased muscle relaxant dose requirement during BIS monitored deep hypnosis produced by Sevoflurane, Isolflurane & Propofol is studied. Material and Methods: 60 adults, 18-70 yrs. belonging to ASA 1,2 posted for laparoscopic cholestectomy, after obtaining written consent & clearance from hospital ethics committee, were included in the study. Patients were premedicated with Tab Diazepam. Beside routine monitoring of pulse, NIBP, continuous neuromuscular monitoring with TOF guard, BIS score with Aspect BIS XP monitor, ET CO2 & MAC anesthetic cone monitored with multi gas analyser (Siemens) were established.
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