Evaluation of antioxidant status in cardiovascular and cerebrovascular disorders

Manocha, Anjali; Srivastava, L.M.; Kankara, Mamta and Bhargava, Seema (2002) Evaluation of antioxidant status in cardiovascular and cerebrovascular disorders. 9th APCCB and 28 th Annual Conference of ACBI, 47.

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Abstract

The exposure of living organisms to reactive oxygen species (ROS) is unavoidable in life, as the generation of ATP from molecular oxygen requires electrons. ROS fall into two categories i.e. those that contain unpaired electrons : (O2,OH) or those that have the ability to extract electrons from other molecules (H2O2, HOCL). These reactive oxygen species could damage biomolecules directly or initiate chain reactions in which ROS are transferred from one molecule to another, resulting in extensive damage to cell structures such as membranes and proteins. This paradoxical need for, a toxic fuel molecule has a central role in biosciences, since life organisms would have to continuously battle to maintain an appropriate balance between pro-oxidants and antioxidants. If the balance sways in the direction of pro-oxidants, "oxidative stress" can occur, which is controlled by antioxidant enzymes, proteins and antioxidants provided by the diet. Deficiency or breakdown of such defenses against ROS could lead to damage, which has been strongly associated with several ailments including cardiovascular and cerebrovascular diseases, which form the major review theme of this paper. (Moreover ROS should not become too low due to its significant roles in the immune system.) Various free radicals are controlled or neutralized by different antioxidants as a group and not individually. Hence monitoring of the antioxidants based on the measurements of total antioxidant capacity is conducive of the high-risk patients as well as evaluation of the therapeutic efficacy and antioxidant potential of the drugs. While evaluating our findings that the total antioxidant capacity is significantly reduced in coronary heart disease it would be of paramount importance to discuss these along with the status in cerebrovascular disease and other chronic diseases viz. Alzheimer, autoimmune diseases, cancer, diabetes, multiple sclerosis and arthritis.

EPrint Type:Article
Uncontrolled Keywords:Cerebrovascular Disorders, Antioxidant Status, Cardiovascular Disorders, Biosciences, Free Radicals, Alzheimer Disease, Autoimmune Diseases, Cancer, Diabetes, Multiple Sclerosis, Arthritis
Subjects:Endocrine Diseases > Diabetes Mellitus
Cardiovascular Diseases > Vascular Diseases > Cerebrovascular Disorders
Nervous System Diseases > Neurodegenerative Diseases > Tauopathies
Nervous System Diseases > Central Nervous System Diseases > Brain Diseases
Cardiovascular Diseases > Heart Diseases > Myocardial Ischemia > Coronary Disease
-Institutional Repositories > Sir Ganga Ram Hospital, New Delhi
Mental Disorders > Delirium, Dementia, Amnestic, Cognitive Disorders
Chemical Actions and Uses > Specialty Uses of Chemicals > Protective Agents
Cardiovascular Diseases > Heart Diseases
Musculoskeletal Diseases > Joint Diseases > Arthritis
ID Code:2361
Deposited By:Sir Ganga Ram Hospital
Deposited On:04 October 2007

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