Studies on hypertriglyceridemia as an independent factor and its association with HDL and lipoprotien(A) as risk factors for CAD in the urban population of Delhi
Manocha, A. and Srivastava, L.M. (2002) Studies on hypertriglyceridemia as an independent factor and its association with HDL and lipoprotien(A) as risk factors for CAD in the urban population of Delhi. Proceedings of 9th APCCB and 28 th Annual Conference of ACBI.
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The prevalence of Coronary Artery Disease (CAD) is known to be especially high in the Indian subcontinent and triglycerides have emerged as a strong and independent risk factor in predicting the disease. Although both fasting and post-prandial triglyceride levels have been associated with increased risk, the current view is that the latter one is the stronger predictor of atherogenesis. In our study, we looked into the evidence leading to triglycerides as a independent risk factor for CAD. In continuation with this, we found, in a crosssectional urban population of Delhi, that a significant number of subjects with triglycerides ^200 mg/dl, were associated with low HDL-cholesterol < 35 mg/dl. This finding also confirms the observation that HDL cholesterol levels are low in Indians with CAD. Lp(a) too was estimated in the same subjects. No significant correlation was observed, thus suggesting that Lp(a) is an independent genetic risk factor for CAD. Further studies are on way to elucidate whether the inverse relationship between triglycerides and HLD-cholesterol is due to the direct effect of hypertriglyceridemia per se.
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