Role of atrial fibrillation threshold evaluation on guiding treatment

Shirayama, Takeshi (2003) Role of atrial fibrillation threshold evaluation on guiding treatment. Indian Pacing and Electrophysiology Journal, 3 (4). pp. 224-230. ISSN 0972-6292

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Atrial fibrillation could be induced reproducibly by 50Hz rapid stimulation which was given through systolic and early diastolic phase of atrial excitation. Duration of atrial fibrillation induced in this way was roughly dependent on the current amplitude of the stimulation. The minimum current that could induce long-lasting atrial fibrillation (30sec in the clinical setting, 2sec in the rabbit or rat model) was defined as atrial fibrillation threshold (AFT). AFT was larger in patients who had history of atrial fibrillation than those who did not. Anti-arrhythmic drugs raised AFT by various degrees both in experimental and clinical cases. Long-term efficacy of a drug could be predicted in a patient, measuring how much the drug increased AFT (cut-off point = 5mA increase). AFT is a useful marker to evaluate atrial vulnerability and to guide pharmacological treatment of atrial fibrillation.

EPrint Type:Article
Uncontrolled Keywords:atrial fibrillation, electrophysiological test, therapy, prognosis
Subjects:Diagnosis > Prognosis
Cardiovascular Diseases > Heart Diseases > Arrhythmia > Atrial Fibrillation
Physiological Processes > Electrophysiology
-Journal Repositories > Indian Pacing and Electrophysiology Journal
ID Code:240
Deposited By:Indian Pacing and Electrophysiology Journal
Deposited On:08 July 2005

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