Clinical spectrum of intrahepatic cholestatis of pregnancy

Anand, V.; Saigal, S.; Saraf, N.; Sud, R.; Sama, S.K. and Arora, A. (2002) Clinical spectrum of intrahepatic cholestatis of pregnancy. Indian Journal of Gastroenterology, 21. A102.

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Introduction: Intrahepatic cholestasis of pregnancy (IHC) is a reversible form of cholestasis seen in late pregnancy &c clears shortly after delivery. Early identification of this condition and careful monitoring can improve maternal and fetal outcome. We studied the clinical and biochemical features of patients presenting with intrahepatic cholestasis of pregnancy. Methods: We prospectively studied patients who presented with intrahepatic cholestasis of pregnancy between November 2001 to July 2002. All patients underwent detailed clinical and biochemical evaluation. Results: A total of 11 patients of IHC were prospectively analyzed. The mean age of patients at presentation was 26 years (range, 20-34 yrs). The majority of the patients (10/11, 91%) presented during 3rd trimester. Of the 11 patients 7 (63.6%) developed IHC during 1st pregnancy, 3 (27.2%) developed IHC during 2nd pregnancy, and 1 patient (9.1%) developed IHC during 3rd pregnancy. Pruritis was universally present and almost 1/3 of the patients had anorexia and nausea. Only 1 patients (9.1%) had icterus clinically. The mean serum bilirubin level was 0.8 mg% (0.3-2.1), SGOT 134+57.7, SGPT 145.8±51.7 and SAP 498.7±305.7. Six out of 11 patients received UDCA with symptomatic improvement in pruritus. Conclusion: IHC is not an uncommon entity in our setup, and increased awareness is needed for proper diagnosis and management of patients.

EPrint Type:Article
Uncontrolled Keywords:Intrahepatic Cholestasis, Pregnancy, Bilirubin Level, Patients, Diagnosis, Management, Pruritus
Subjects:Diagnosis > Diagnostic Techniques and Procedures
Growth Substances, Pigments, and Vitamins > Pigments > Bile Pigments
Digestive System Diseases > Liver Diseases > Cholestasis, Intrahepatic
Reproductive and Urinary Physiology > Reproduction > Pregnancy
Persons > Patients
-Institutional Repositories > Sir Ganga Ram Hospital, New Delhi
ID Code:2415
Deposited By:Sir Ganga Ram Hospital
Deposited On:22 October 2007

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