Efficacy of levofloxacin monotherapy in pneumonias

Kakar, A.; Byotra, S.P. and Prakash, V. (2002) Efficacy of levofloxacin monotherapy in pneumonias. Journal of the Association of Physicians of India, 50. 185.

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Levofloxacin is a new fluroquinolones which has a broad spectrum of activity against respiratory pathogens. The aim of the study was to document the clinical efficacy, tolerance and safety profile of levofloxacin in pneumonias. The study was conducted between December 2000 to June 2001. The sputum was examined for Gram's stain and culture. Levofloxacin was administered 500 mg once daily. The duration of therapy ranged from 7 to 10 days. Thirty patients (18 males, 12 females) were taken up for this study. The age varied from 18 years to 78 years. The average age of patients was 44 years. The diagnosis of community acquired pneumonia was made in 24 cases and nosocomial pneumonia in 5 patients. Four of them had received .antibiotic from outside (Doxycycline - 2, Ciprofloxacin -1, Amoxycillin -1). The concomitant disorders were chronic obstructive airway disease in 12 cases, diabetes mellitus - eight cases, allergy - six patients. The concomitant antibiotic were used in two cases (aminoglycosides -1, macrolides -1). The fever was present in 28 cases on day 1,12 patients on day 3 and none by day 10. The cough and dyspnea was scored as 0-none, l-mild, 2-moderate and 3 as severe. There was improvement in both cough and dyspnea score by day 3 and significant improvement by day 7. The sputum production also less by day 3 of levofloxacin. The pre-treatment bacteriological data was collected in all patients but growth of organism was obtained in 12 cases. Streptococcuspneumoniae was the commonest organism - eight cases. The over all physician's efficacy was excellent 8/ 30, very much improvement -16/30 and improved in six cases. No adverse events was noticed due to levofloxacin use and it was not prematurely discontinued in any patient.

EPrint Type:Article
Uncontrolled Keywords:Levofloxacin, Pneumonia, Fluroquinolones, Doxycyline, Ciprofloxacin, Amoxycillin
Subjects:Heterocyclic Compounds > Heterocyclic Compounds, 2-Ring > Bicyclo Compounds, Heterocyclic
Organic Chemicals > Sulfur Compounds
Heterocyclic Compounds > Heterocyclic Compounds, Bridged-Ring > Bicyclo Compounds, Heterocyclic
Respiratory Tract Diseases > Lung Diseases > Pneumonia
Organic Chemicals > Amides > Lactams
Heterocyclic Compounds > Heterocyclic Compounds, 2-Ring > Quinolines > Quinolones > Fluoroquinolones
Heterocyclic Compounds > Heterocyclic Compounds, 2-Ring > Quinolines > Quinolones > Fluoroquinolones > Ofloxacin
Inorganic Chemicals > Sulfur Compounds
-Institutional Repositories > Sir Ganga Ram Hospital, New Delhi
Heterocyclic Compounds > Heterocyclic Compounds, 2-Ring > Quinolines > Quinolones > Fluoroquinolones > Ciprofloxacin
Respiratory Tract Diseases > Respiratory Tract Infections > Pneumonia
ID Code:2417
Deposited By:Sir Ganga Ram Hospital
Deposited On:22 October 2007

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