Organizational effort in a clinical trial and its relevance to applicability of short-course chemotherapy in national tuberculosis programme

Aneja, K.S. and Rupert Samuel, G.E. (1982) Organizational effort in a clinical trial and its relevance to applicability of short-course chemotherapy in national tuberculosis programme. Indian Journal of Tuberculosis, 29 (1). pp. 19-28.

Full text available as:

PDF - Requires Adobe Acrobat Reader or other PDF viewer.
166 Kb


The high rate of treatment completions and the regularity of treatment achieved in clinical trials of Short-Course Chemotherapy, could possibly be attributed to efficient organizational set-up, careful selection of cases and all-out effort to control defaulters. The organizational effort put forth to achieve the regularity is relevant to the applicability of Short-Course Chemotherapy in the existing set-up of District Tuberculosis Centres under National Tuberculosis Programme. First 300 patients admitted to a Short-Course Chemotherapy trial to assess the efficacy of three drug regimens of 3/5 months duration under fully supervised conditions, being carried out jointly by the Tuberculosis Research Centre, Madras and National Tuberculosis Institute, Bangalore, have been analysed for that purpose. To keep up the regularity, 1/3 of the patients required home visits— some of them repeatedly. If the same type of defaulter retrieval actions are envisaged to be taken in the normal working conditions of a District Tuberculosis Centre catering to 500 patients in any one observation month. 350 to 300 home visits will have to be made in a month. This may not be feasible in the existing set-up of National Tuberculosis Programme. A new strategy of defaulter retrieval actions for programme conditions may have to be devised. Further, selection of drug regimen which has the maximum potential of being given on self-administered basis may reduce the work-load to a considerable extent. Drug toxicity/side-effects and the cost of drugs may not be major handicaps. However, the only way to understand various operational problems is to undertake scientific operational studies in actual working conditions of National Tuberculosis Programme

EPrint Type:Article
Uncontrolled Keywords:Short Course Chemotherapy, Pulmonary Tuberculosis, Organizational Ability, Clinical Trial, National Tuberculosis Programme, Side Effects, Drug Regime, Drug Toxicity, Rifampicin, Default
Subjects:Disorders of Environmental Origin > Poisoning > Drug Toxicity
Investigative Techniques > Evaluation Studies > Clinical Trials
Therapeutics > Drug Therapy
Health Care Economics and Organizations > Organizations
Social Sciences > Government Programs
Health Care Economics and Organizations > Health Planning > National Health Programs
Heterocyclic Compounds > Heterocyclic Compounds with 4 or More Rings > Rifamycins
Respiratory Tract Diseases > Respiratory Tract Infections > Tuberculosis, Pulmonary
Health Services Administration > Organization and Administration
Investigative Techniques > Drug Administration Schedule
Respiratory Tract Diseases > Lung Diseases > Tuberculosis, Pulmonary
-Journal Repositories > Indian Journal of Tuberculosis
ID Code:2506
Deposited By:Mrs Naina Pandita
Deposited On:19 December 2007

Archive Staff Only: edit this record