Organizational effort in a clinical trial and its relevance to applicability of short-course chemotherapy in national tuberculosis programme
Aneja, K.S. and Rupert Samuel, G.E. (1982) Organizational effort in a clinical trial and its relevance to applicability of short-course chemotherapy in national tuberculosis programme. Indian Journal of Tuberculosis, 29 (1). pp. 19-28.
Full text available as:
The high rate of treatment completions and the regularity of treatment achieved in clinical trials of Short-Course Chemotherapy, could possibly be attributed to efficient organizational set-up, careful selection of cases and all-out effort to control defaulters. The organizational effort put forth to achieve the regularity is relevant to the applicability of Short-Course Chemotherapy in the existing set-up of District Tuberculosis Centres under National Tuberculosis Programme. First 300 patients admitted to a Short-Course Chemotherapy trial to assess the efficacy of three drug regimens of 3/5 months duration under fully supervised conditions, being carried out jointly by the Tuberculosis Research Centre, Madras and National Tuberculosis Institute, Bangalore, have been analysed for that purpose. To keep up the regularity, 1/3 of the patients required home visits— some of them repeatedly. If the same type of defaulter retrieval actions are envisaged to be taken in the normal working conditions of a District Tuberculosis Centre catering to 500 patients in any one observation month. 350 to 300 home visits will have to be made in a month. This may not be feasible in the existing set-up of National Tuberculosis Programme. A new strategy of defaulter retrieval actions for programme conditions may have to be devised. Further, selection of drug regimen which has the maximum potential of being given on self-administered basis may reduce the work-load to a considerable extent. Drug toxicity/side-effects and the cost of drugs may not be major handicaps. However, the only way to understand various operational problems is to undertake scientific operational studies in actual working conditions of National Tuberculosis Programme
Archive Staff Only: edit this record