Agra study of short-course chemotherapy in pulmonary tuberculosis patients
Mehrotra, M.L. (1982) Agra study of short-course chemotherapy in pulmonary tuberculosis patients. Indian Journal of Tuberculosis, 29 (1). pp. 29-39.
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Summary : The efficacy of five short course chemotherapeutic regimens, is compared. In two 4.5 month regimens and in one 3 month regimen the four most potent anti-tuberculous drugs, isoniazid, rifampin, pyrazinamide and Streptomycin were given daily for the initial 3 months of treatment. In another 4.5 month regimen and 3 month regimen a fifth drug, ethionamide, was given along with the above four drugs for the initial 3 months. After initial 3 months, the subsequent 1.5 month treatment in two 4.5 month regimens consisted of isoniazid, pyrazinamide and streptomycin intermittently twice weekly. Bacillary conversion was achieved in 96 percent patients at 2 months and in 99 percent at 3 months, and it was of a similar order at each stage of treatment both in 4 and 5 drug regimens. Drug compliance in 4 drug regimens was substantially higher (91 percent) as compared to 5 drug regimens (81 percent). A relapse rate of 5 percent followed the 3 month regimen during 12 month follow-up period after completion of treatment as against 3 percent in 4.5 month regimens.
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