Short term chemotherapy in children : three years follow up

Dingley, H.B. (1982) Short term chemotherapy in children : three years follow up. Indian Journal of Tuberculosis, 29 (1). pp. 48-54.

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Abstract

The results of treatment of 134 children suffering from the childhood and adult type of pulmonary tuberculosis randomly allocated to one of the following four drug regimens have been reviewed at the end of three years: Group A: INH + PAS + Thiacetazone. Group B: INH + Pyrazinamide+Ethambulol. Group C; INH + Pyrazinamide + Rifampicin. Group D : INH + Thiacetazone. Patients in groups A,B,C, received drugs for 26 weeks followed by placebo for 26 weeks. Patients in group D received drugs for 78 weeks. AH patients were kept in the hospital for 26 weeks. Bacteriolological confirmation was obtained in 4, 6, 6 and 3 patients respectively. Radiologically, group C had more patients with extensive, bilateral disease and mediastinal glandular enlargement. Though bacteriological conversion was similar in groups B, C and D, radiological regression was more in group C.

EPrint Type:Article
Uncontrolled Keywords:Children, Adult, Pulmonary Tuberculosis, Short-term Chemotherapy, INH, PAS, Thiacetazone, Rifampicin, Pyrazinamide, Ethambulol, Follow-up, Three Years, Radiological Regression, Bacteriology
Subjects:Therapeutics > Drug Therapy
Persons > Age Groups > Child
Organic Chemicals > Hydrazines > Isoniazid
Organic Chemicals > Amines > Polyamines
Heterocyclic Compounds > Heterocyclic Compounds with 4 or More Rings > Rifamycins
Respiratory Tract Diseases > Respiratory Tract Infections > Tuberculosis, Pulmonary
Organic Chemicals > Carboxylic Acids > Hydroxy Acids > Hydroxybenzoic Acids > Salicylic Acids > Aminosalicylic Acids > p-Aminosalicylic Acid
Pharmaceutical Preparations > Drug Combinations
Investigative Techniques > Drug Administration Schedule
Heterocyclic Compounds > Heterocyclic Compounds, 1-Ring > Pyrazines
Organic Chemicals > Sulfur Compounds > Thiosemicarbazones
Respiratory Tract Diseases > Lung Diseases > Tuberculosis, Pulmonary
-Journal Repositories > Indian Journal of Tuberculosis
ID Code:2509
Deposited By:Mrs Naina Pandita
Deposited On:20 December 2007

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