Short term chemotherapy in children : three years follow up
Dingley, H.B. (1982) Short term chemotherapy in children : three years follow up. Indian Journal of Tuberculosis, 29 (1). pp. 48-54.
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The results of treatment of 134 children suffering from the childhood and adult type of pulmonary tuberculosis randomly allocated to one of the following four drug regimens have been reviewed at the end of three years: Group A: INH + PAS + Thiacetazone. Group B: INH + Pyrazinamide+Ethambulol. Group C; INH + Pyrazinamide + Rifampicin. Group D : INH + Thiacetazone. Patients in groups A,B,C, received drugs for 26 weeks followed by placebo for 26 weeks. Patients in group D received drugs for 78 weeks. AH patients were kept in the hospital for 26 weeks. Bacteriolological confirmation was obtained in 4, 6, 6 and 3 patients respectively. Radiologically, group C had more patients with extensive, bilateral disease and mediastinal glandular enlargement. Though bacteriological conversion was similar in groups B, C and D, radiological regression was more in group C.
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