Alternations in hemostatic mechanism during pyrazinamide therapy

Sharma, T.N.; Jain, N.K.; Kumar, P.; Purohit, S.D.; Khandelwal, B.D.; Mathur, B.B. and Madan, A. (1982) Alternations in hemostatic mechanism during pyrazinamide therapy. Indian Journal of Tuberculosis, 29 (2). pp. 104-110.

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Bleeding time, Coagulation time, Prothrombin time, Serum calcium, Plasma fibrinogen, Platelet counts, Platelet aggregation. Platelet adhesive index estimations were done in 10 normal healthy controls and 90 cases of pulmonary tuberculosis, to study alterations in Hemostatic mechanism before and after pyrazinamide therapy. Pyrazinamide even in therapeutic doses affected the entire hemostatic mechanism. Hypoprothrombinemia, thromobocytopenia, decreased adhesiveness of platelets and inhibition of platelet aggregation were observed. Hemoptysis was seen in 12.2% cases and in 4.4% it could be specifically attributed to pyrazinamide.

EPrint Type:Article
Uncontrolled Keywords:Pyrazinamide Therapy, Pyrazinamide, Pulmonary Tuberculosis, Hemostatic Mechanism, Coagulation Time, Platelet Aggregation, Serum Calcium, Platelet Counts, Plasma Fibrinogen, Hemoptysis, Hypothrombinemia, Thrombocytopenia
Subjects:Therapeutics > Drug Therapy
Hematologic, Gastrointestinal, and Renal Agents > Hematologic Agents > Coagulants
Respiratory Tract Diseases > Respiratory Tract Infections > Tuberculosis, Pulmonary
Investigative Techniques > Clinical Laboratory Techniques
Circulatory and Respiratory Physiology > Blood Physiology
Hemic and Lymphatic Diseases > Hematologic Diseases > Blood Platelet Disorders
Biological Phenomena, Cell Phenomena, and Immunity > Cell Physiology
Heterocyclic Compounds > Heterocyclic Compounds, 1-Ring > Pyrazines
Hemic and Lymphatic Diseases > Hematologic Diseases > Blood Coagulation Disorders
Respiratory Tract Diseases > Lung Diseases > Tuberculosis, Pulmonary
-Journal Repositories > Indian Journal of Tuberculosis
Diagnosis > Laboratory Techniques and Procedures
ID Code:2518
Deposited By:Mrs Naina Pandita
Deposited On:27 December 2007

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