Rate of inactivation of isoniazid in Southern Rajasthan patients with pulmonary tuberculosis
Agarwal, B.L.; Chaudhry, B.S.; Jhamaria, J.P.; Luhdia, S.K. and Gupta, V.K. (1983) Rate of inactivation of isoniazid in Southern Rajasthan patients with pulmonary tuberculosis. Indian Journal of Tuberculosis, 30 (1). pp. 21-24.
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One hundred fresh sputum positive cases of Pulmonary Tuberculosis have been studied to carry out estimation of acetylated sulphadimidine in blood and urine. It was observed that 58 % were classified as slow acetylutors of sulphadimidine according to blood estimation, compared with 60% according to urine estimation. The values are almost identical in males and females. Though the acetylation pattern in both blood as well as urine runs almost parallel, blood estimation was found to be relatively superior to urine estimation of acetylated sulphadimidine. However, since urine estimation is easy and convenient, it may be considered reliable in field practice.
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