Short course chemotherapy of pulmonary tuberculosis: interim report on second Tuberculosis Association of India trial
Vishwanathan, R.; Pamra, S.P.; Dingley, H.B. and Singh, S.M. (1983) Short course chemotherapy of pulmonary tuberculosis: interim report on second Tuberculosis Association of India trial. Indian Journal of Tuberculosis, 30 (2). pp. 57-62.
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Two short course regimens were studied. In one, RMP, 1NH and PZA were given daily for eight weeks. In the other SM was added in the first 8 weeks. Those whose sputum was converted by direct smear at 8 weeks were trealed randomly with RMP and INH daily for a further 4 or 18 weeks in both regimens. Patients who continued to have a positive smear at 8 weeks were treated with RMP and INH daily for 18 weeks after the initial intensive phase of 8 weeks. Only 1 patient remained unconverted at the termination of chemotherapy. There was no bacteriological reversion during six months of follow up after termination of chemotherapy if the total duration was 26 weeks. Nearly one-fourth of the patients had bacteriological reversion among those treated for 12 weeks only. Bacilli in most of the relapse cases were sensitive to all drugs at the time of relapse. Streptomycin group had no overall advantage over the others except that sputum conversion at 8 weeks was higher in the former. All patients who harboured initially drug resistant bacilli were converted if their treatment was for 26 weeks.
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