Short course chemotherapy of pulmonary tuberculosis: interim report on second Tuberculosis Association of India trial

Vishwanathan, R.; Pamra, S.P.; Dingley, H.B. and Singh, S.M. (1983) Short course chemotherapy of pulmonary tuberculosis: interim report on second Tuberculosis Association of India trial. Indian Journal of Tuberculosis, 30 (2). pp. 57-62.

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Two short course regimens were studied. In one, RMP, 1NH and PZA were given daily for eight weeks. In the other SM was added in the first 8 weeks. Those whose sputum was converted by direct smear at 8 weeks were trealed randomly with RMP and INH daily for a further 4 or 18 weeks in both regimens. Patients who continued to have a positive smear at 8 weeks were treated with RMP and INH daily for 18 weeks after the initial intensive phase of 8 weeks. Only 1 patient remained unconverted at the termination of chemotherapy. There was no bacteriological reversion during six months of follow up after termination of chemotherapy if the total duration was 26 weeks. Nearly one-fourth of the patients had bacteriological reversion among those treated for 12 weeks only. Bacilli in most of the relapse cases were sensitive to all drugs at the time of relapse. Streptomycin group had no overall advantage over the others except that sputum conversion at 8 weeks was higher in the former. All patients who harboured initially drug resistant bacilli were converted if their treatment was for 26 weeks.

EPrint Type:Article
Uncontrolled Keywords:Pulmonary Tuberculosis, Short Course Chemotherapy, INH, PZA, Rifampicin, Streptomycin, Ethambutol, Pyrazinamide, Drug Regimen, Tuberculosis Association of India, Interim Report
Subjects:Therapeutics > Drug Therapy
Organic Chemicals > Hydrazines > Isoniazid
Therapeutics > Combined Modality Therapy
Organic Chemicals > Amines > Polyamines
Heterocyclic Compounds > Heterocyclic Compounds with 4 or More Rings > Rifamycins
Respiratory Tract Diseases > Respiratory Tract Infections > Tuberculosis, Pulmonary
Pharmaceutical Preparations > Drug Combinations
Carbohydrates and Hypoglycemic Agents > Carbohydrates > Glycosides > Aminoglycosides > Streptomycin
Investigative Techniques > Drug Administration Schedule
Heterocyclic Compounds > Heterocyclic Compounds, 1-Ring > Pyrazines
Chemical and Pharmacologic Phenomena > Drug Design
Respiratory Tract Diseases > Lung Diseases > Tuberculosis, Pulmonary
-Journal Repositories > Indian Journal of Tuberculosis
ID Code:2626
Deposited By:Mrs Naina Pandita
Deposited On:26 February 2008

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