Rifampicin: its biochemical and microbiological bioavailability in pulmonary tuberculosis patients

Koicha, M.; Parikh, S.C. and Patil, A.G. (1983) Rifampicin: its biochemical and microbiological bioavailability in pulmonary tuberculosis patients. Indian Journal of Tuberculosis, 30 (2). pp. 63-68.

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Abstract

After determination of the purity of the Rifampicin received from two different pharmaceutical sources, the drug was administered to two groups of patients in double-blind cross over fashion. The serum Rifampicin concentrations were determined biochemically and micro biologically. Twenty-four hour's urinary excretion of Rifampicin was assessed followed by the chromatographic separation of "various Rifampicin metabolites. There was marked difference between the two preparations in respect of all these values. The binding capacities of Rifampicin with various protein fractions were elucidated by carrying out in vivo and in vitro experiments. The results of these experimental data have been discussed. Initially albumin is the first protein fraction which binds Rifampicin. However alpha-2 protein fraction also plays an important role in binding of Rifampicin, which may be in the labile complex form.

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