Drug-parasite-host interactions in tuberculosis

Gangadharam, Pattisapu R. (1983) Drug-parasite-host interactions in tuberculosis. Indian Journal of Tuberculosis, Supplement, 30 (3). pp. 3-11.

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In summary, chemotherapy of tuberculosis can be considered as a positive beneficial balance of the drug parasite host interactions in favour of the host and against the parasite. The host defense cell, the macrophage, is capable of inhibiting and digesting the bacteria, when the bacterial challenges are in low numbers. Its action however is not at all helpful to the host when it fails to control the large bacterial loads. In such a situation, it will be a great hindrance in that the shielded bacteria inside the macrophages are protected from the action of the drugs, thereby creating many problems to the host and to the clinicians. Contrary to the original expectations and formulations of Paul Ehrlich the father of chemotherapy, the actions of the host with respect to the drug will not help the host in all respects and quite frequently prevent the action of the drug by metabolizing and eliminating it. To achieve success, to fulfill and realize the fruits of chemotherapy, the patient should avoid the voluntary defaults at least.

EPrint Type:Article
Additional Information:*Based on the Ranbaxy-Robert Koch Oration delivered at the 37th Tuberculosis Conference, New Delhi. **Director, Mycobacteriology Research, National Jewish Hospital and Research Centre/National Asthma Centre, Denver, Colorado.
Uncontrolled Keywords:Chemotherapy, Tuberculosis, Pulmonary Tuberculosis, Drug Parasite Host Interactions, Isoniazid, Tubercule Bacilli, Man. Immunity
Subjects:Bacterial Infections and Mycoses > Bacterial Infections > Gram-Positive Bacterial Infections > Actinomycetales Infections > Mycobacterium Infections > Tuberculosis
Therapeutics > Drug Therapy
Organic Chemicals > Hydrazines > Isoniazid
Bacteria > Gram-Positive Bacteria > Actinobacteria > Actinomycetales > Mycobacteriaceae > Mycobacterium > Mycobacterium tuberculosis
Biological Phenomena, Cell Phenomena, and Immunity > Immunity
Respiratory Tract Diseases > Respiratory Tract Infections > Tuberculosis, Pulmonary
Immunologic Diseases > Hypersensitivity > Drug Hypersensitivity
Respiratory Tract Diseases > Lung Diseases > Tuberculosis, Pulmonary
-Journal Repositories > Indian Journal of Tuberculosis
ID Code:2631
Deposited By:Mrs Naina Pandita
Deposited On:26 February 2008

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