Drug-parasite-host interactions in tuberculosis
Gangadharam, Pattisapu R. (1983) Drug-parasite-host interactions in tuberculosis. Indian Journal of Tuberculosis, Supplement, 30 (3). pp. 3-11.
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In summary, chemotherapy of tuberculosis can be considered as a positive beneficial balance of the drug parasite host interactions in favour of the host and against the parasite. The host defense cell, the macrophage, is capable of inhibiting and digesting the bacteria, when the bacterial challenges are in low numbers. Its action however is not at all helpful to the host when it fails to control the large bacterial loads. In such a situation, it will be a great hindrance in that the shielded bacteria inside the macrophages are protected from the action of the drugs, thereby creating many problems to the host and to the clinicians. Contrary to the original expectations and formulations of Paul Ehrlich the father of chemotherapy, the actions of the host with respect to the drug will not help the host in all respects and quite frequently prevent the action of the drug by metabolizing and eliminating it. To achieve success, to fulfill and realize the fruits of chemotherapy, the patient should avoid the voluntary defaults at least.
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