Hepatitis during isoniazid, pyrazinamide and rifampicin therapy

Khanna, B.K. (1983) Hepatitis during isoniazid, pyrazinamide and rifampicin therapy. Indian Journal of Tuberculosis, 30 (3). pp. 104-106.

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A review of hospital records for the years 1980-81 has revealed that 10% of the cases receiving a combination of isoniazid, pyrazinamide and rifampicin, with or without other anti-tuberculosis drugs, administered daily, had developed hepatitis. In addition, Two of the 10 patients receiving isoniazid and rifampicin daily in combination with other anti-tuberculosis drugs had developed hepatitis, the overall prevalence of jaundice in those receiving rifampicin therapy being 11.4% (8 out of 70 cases). In contrast, none of the cases receiving isoniazid and pyra2inamide in the same doses in conjunction with other anti-tuberculosis drugs daily had developed hepatitis. It is concluded that addition of rifampicin to anti-tuberculosis chemotherapy was likely to lead to hypersensitivity included hepatitis in some cases.

EPrint Type:Article
Uncontrolled Keywords:Hepatitis, Drug Toxicity, Isoniazid, Rifampcin, Tuberculosis, Pulmonary Tuberculosis, Pyrazinamide, Anti-tuberculosis Drugs, Jaundice, Prevalence, Drug Combinations
Subjects:Disorders of Environmental Origin > Poisoning > Drug Toxicity
Therapeutics > Drug Therapy
Organic Chemicals > Hydrazines > Isoniazid
Digestive System Diseases > Liver Diseases > Hepatitis
Heterocyclic Compounds > Heterocyclic Compounds with 4 or More Rings > Rifamycins
Respiratory Tract Diseases > Respiratory Tract Infections > Tuberculosis, Pulmonary
Investigative Techniques > Epidemiologic Methods > Data Collection > Vital Statistics > Morbidity > Prevalence
Pharmaceutical Preparations > Drug Combinations
Heterocyclic Compounds > Heterocyclic Compounds, 1-Ring > Pyridines
Respiratory Tract Diseases > Lung Diseases > Tuberculosis, Pulmonary
-Journal Repositories > Indian Journal of Tuberculosis
Digestive System Diseases > Liver Diseases
ID Code:2638
Deposited By:Mrs Naina Pandita
Deposited On:28 February 2008

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