Cardiac resynchroniztion therapy in heart failure: recent advances and new insights

Bhatia, V.; Bhatia, R.; Dhindsa, S. and Virk, A. (2003) Cardiac resynchroniztion therapy in heart failure: recent advances and new insights. Indian Pacing and Electrophysiology Journal, 3 (3). pp. 129-142. ISSN 0972-6292

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Newer non-pharmacological therapies for heart failure are being evaluated for patients of congestive heart failure (CHF). Mechanical support with left ventricular assist devices and heart transplantation are reserved for the minority of patients who have severely decompensated heart failure1. Despite these therapeutic advances, it is generally accepted that current therapies do not adequately address the clinical need of patients with heart failure, and additional strategies are being developed. Cardiac resynchronization therapy (CRT) is a new modality that involves synchronization of ventricular contraction and has shown a lot of promise in managing symptomatic patients of CHF who are on optimal medical therapy and have interventricular conduction delay (IVCD). It has improved exercise tolerance and NYHA functional class in such patients in sinus rhythm and a recent meta-analysis has also shown mortality benefits in CHF. Recently benefits of CRT have also been observed in CHF patients who do not have wide QRS complexes on electrocardiogram (EKG). It has also been shown to benefit drug refractory angina in CHF. Recent studies have also focused on the combined use of CRT and implantable cardioverter defibrillator (ICD) and it has shown encouraging results. Our aim in this descriptive review is to define practice guidelines and to improve clinicians' knowledge of the available published clinical evidence, concentrating on few randomized controlled trials.

EPrint Type:Article
Uncontrolled Keywords:Cardiac Resynchroniztion Therapy; Heart Failure
Subjects:Cardiovascular Diseases > Heart Diseases > Heart Failure, Congestive
Diagnosis > Diagnostic Techniques and Procedures > Diagnostic Techniques, Cardiovascular > Heart Function Tests > Electrocardiography
-Journal Repositories > Indian Pacing and Electrophysiology Journal
Cardiovascular Diseases > Heart Diseases > Arrhythmia > Heart Block > Bundle-Branch Block
Therapeutics > Cardiac Pacing, Artificial
ID Code:266
Deposited By:Indian Pacing and Electrophysiology Journal
Deposited On:12 July 2005

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