Anti-tuberculosis drugs: mechanisms of action and research trends

Sensi, P. (1983) Anti-tuberculosis drugs: mechanisms of action and research trends. Indian Journal of Tuberculosis, Supplement, 30 (3). pp. 24-28.

Full text available as:

PDF - Requires Adobe Acrobat Reader or other PDF viewer.
257 Kb

Abstract

Several anti-tuberculosis agents haw been discovered and introduced in the therapy in the period between 1944 (streptomycin) to 1965 (rifampicin). Studies on the biosynthesis of the specific constituents of the mycobacterial cell, such as the mycolic acids and the mycobactins, are of particular relevance for designing and testing new specific anti-mycobacterial agents. Also, the understanding of the mechanism of action of the well established drugs could possibly lead to the design of new agents and overcome the resistance problems. The search for new anti-mycobacterial agents is still necessary due to the increasing resistance of mycobacteria to the available drugs and to the not negligible side effects and toxicity of the proposed regimens. The search for new anti-tuberculosis drugs on rational basis is a long lasting process. For the time being a necessary approach is not only to optimise the clinical use of the available drugs, but also to improve their quality and their fields of utilisation.

EPrint Type:Article
Uncontrolled Keywords:Ant-tuberculosis Agents, Rifampicin, Mycobactins, Anti-mycobacterial agents, Anti-tuberculosis Drugs, Streptomycin, p-Aminosalicylic acid, Thioacetazone, Viomycin ,Pyrazinamide, Isoniazid, Cycloserine, Ethionamide, Kanamycin, Capreomycin, Ethambutol
Subjects:Heterocyclic Compounds > Acids, Heterocyclic > Isonicotinic Acids
Therapeutics > Drug Therapy
Chemical Actions and Uses > Pharmacologic Actions > Therapeutic Uses > Anti-Infective Agents > Anti-Bacterial Agents
Chemical and Pharmacologic Phenomena > Drug Resistance
Organic Chemicals > Hydrazines > Isoniazid
Heterocyclic Compounds > Heterocyclic Compounds with 4 or More Rings > Rifamycins
Pharmaceutical Preparations > Drug Combinations
Organic Chemicals > Carboxylic Acids > Hydroxy Acids > Hydroxybenzoic Acids > Salicylic Acids > Aminosalicylic Acids > p-Aminosalicylic Acid
Immunologic Diseases > Hypersensitivity > Drug Hypersensitivity
Chemical and Pharmacologic Phenomena > Biopharmaceutics
Heterocyclic Compounds > Heterocyclic Compounds, 1-Ring > Azoles
Amino Acids, Peptides, and Proteins > Peptides > Peptides, Cyclic
Organic Chemicals > Sulfur Compounds > Thiosemicarbazones
Organic Chemicals > Amines > Polyamines
Carbohydrates and Hypoglycemic Agents > Carbohydrates > Glycosides > Aminoglycosides
Respiratory Tract Diseases > Respiratory Tract Infections > Tuberculosis, Pulmonary
Biochemical Phenomena, Metabolism, and Nutrition > Metabolism
Carbohydrates and Hypoglycemic Agents > Carbohydrates > Glycosides > Aminoglycosides > Streptomycin
Heterocyclic Compounds > Heterocyclic Compounds, 1-Ring > Pyridines
Heterocyclic Compounds > Heterocyclic Compounds, 1-Ring > Pyrazines
Chemical and Pharmacologic Phenomena > Drug Design
Respiratory Tract Diseases > Lung Diseases > Tuberculosis, Pulmonary
-Journal Repositories > Indian Journal of Tuberculosis
ID Code:2673
Deposited By:Mrs Naina Pandita
Deposited On:05 March 2008

Archive Staff Only: edit this record