Glucose tolerance during rifampicin therapy
Purohit, S.D.; Gupta, P.R.; Agarwal, K.C.; Sharma, T.N.; Durlabji, P. and Sharma, Ashok (1984) Glucose tolerance during rifampicin therapy. Indian Journal of Tuberculosis, 31 (1). pp. 3-5.
Full text available as:
Fifty seven Smear positive patients of pulmonary tuberculosis were randomly put on one of two anti-tuberculous drug regimens. Regimen I (SHR) consisted of streptomycin, isoniazid & rifampicin. In regimen II (SHE) rifampicin was replaced by ethambutol Glucose tolerance was tested in all the patients initially & after 7 & 30 days of chemotherapy. After 7 days of rifampicin therapy, the mean rise in serum glucose was higher than that before chemotherapy at any time interval after glucose ingestion. On 30th day, the mean rise in serum glucose was lower as compared to pretreatment rise in patients on both the drug regiment (P>0.05). Early phase hyperglycemia was observed in 3 out of 30 patients on rifampicin therapy but4n none of the 27 patients on drug regimen II. It disappeared by itself in all the patients on 30th day of therapy, even when rifampicin administration was continued.
Archive Staff Only: edit this record