Glucose tolerance during rifampicin therapy

Purohit, S.D.; Gupta, P.R.; Agarwal, K.C.; Sharma, T.N.; Durlabji, P. and Sharma, Ashok (1984) Glucose tolerance during rifampicin therapy. Indian Journal of Tuberculosis, 31 (1). pp. 3-5.

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Fifty seven Smear positive patients of pulmonary tuberculosis were randomly put on one of two anti-tuberculous drug regimens. Regimen I (SHR) consisted of streptomycin, isoniazid & rifampicin. In regimen II (SHE) rifampicin was replaced by ethambutol Glucose tolerance was tested in all the patients initially & after 7 & 30 days of chemotherapy. After 7 days of rifampicin therapy, the mean rise in serum glucose was higher than that before chemotherapy at any time interval after glucose ingestion. On 30th day, the mean rise in serum glucose was lower as compared to pretreatment rise in patients on both the drug regiment (P>0.05). Early phase hyperglycemia was observed in 3 out of 30 patients on rifampicin therapy but4n none of the 27 patients on drug regimen II. It disappeared by itself in all the patients on 30th day of therapy, even when rifampicin administration was continued.

EPrint Type:Article
Uncontrolled Keywords:Pulmonary Tuberculosis, Drug Regimens, Streptomycin, Isoniazid, Ethambutol, Glucose Tolerance, Smear, Chemotherapy, Rifampicin, Hyperglycemia
Subjects:Organic Chemicals > Hydrazines > Isoniazid
Heterocyclic Compounds > Heterocyclic Compounds with 4 or More Rings > Rifamycins
Pharmaceutical Preparations > Drug Combinations
Investigative Techniques > Drug Administration Schedule
Carbohydrates and Hypoglycemic Agents > Carbohydrates > Blood Glucose
Nutritional and Metabolic Diseases > Metabolic Diseases > Glucose Metabolism Disorders
Organic Chemicals > Amines > Polyamines
Respiratory Tract Diseases > Respiratory Tract Infections > Tuberculosis, Pulmonary
Carbohydrates and Hypoglycemic Agents > Carbohydrates > Glycosides > Aminoglycosides > Streptomycin
Chemical and Pharmacologic Phenomena > Drug Design
Respiratory Tract Diseases > Lung Diseases > Tuberculosis, Pulmonary
-Journal Repositories > Indian Journal of Tuberculosis
ID Code:2727
Deposited By:Mrs Naina Pandita
Deposited On:12 March 2008

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