Comparison of the influences of new generation antipsychotics and haloperidol on prolactin levels

Kurt, E (2008) Comparison of the influences of new generation antipsychotics and haloperidol on prolactin levels. Anatolian Journal of Psychiatry, 9 (1). pp. 44-48.

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Abstract

Objective: The aim of this naturalistic study was to compare the influence of haloperidol and new generation antipsychotics on prolactin levels is in patients with schizophrenia or delusional disorder. Methods: The participants were 109 patients who were drug free at least for one week (for depot/long action antipsychotic users, drug free at least one month) at the beginning. The data of 64 patients who were receiving haloperidol, clozapine, olanzapine, risperidone, quetiapine or sulpiride were analyzed. No intervention was made to the treatment regimens of the patients. The blood prolactin levels of the patients were measured at the beginning and after the second month of the treatment who had complied with the treatment regimens. Results: In haloperidol, risperidone, and sulpiride groups, the blood prolactin level was found to be increased significantly after two months. There were no significant changes in prolactin levels among clozapine, olanzapine and quetiapine receivers two moths later. Conclusion: Within the widespread use of antipsychotics in schizophrenia and other psychotic disorders, the endocrinological side effects related with drug use like hyperprolactinemia should be kept in mind. Hyperprolactinemia without any comorbidity is not seen a serious problem to cease the treatment. However, the treatment should be revised in a patient with hyperprolactinemia and if needed, further endocrinological examinations should be made.

EPrint Type:Article
Uncontrolled Keywords:Haloperidol, Antipsychotics, Prolactin, Antipsychotic Drugs, Clozapine, Risperidone, Quetiapine, Sulpiride, Hyperprolactinemia, Psychotic Disorders, Schizophrenia
Subjects:Mental Disorders > Schizophrenia and Disorders with Psychotic Features
-Journal Repositories > Anatolian Journal of Psychiatry
Central Nervous System Agents > Psychotropic Drugs > Tranquilizing Agents
Heterocyclic Compounds > Heterocyclic Compounds, 1-Ring > Pyrimidines
Hormones, Hormone Substitutes, and Hormone Antagonists > Hormones > Peptide Hormones
Heterocyclic Compounds > Heterocyclic Compounds, 3-Ring > Dibenzazepines
Endocrine Diseases > Pituitary Diseases > Hyperpituitarism
Central Nervous System Agents > Central Nervous System Depressants > Tranquilizing Agents
Heterocyclic Compounds > Heterocyclic Compounds, 1-Ring > Thiepins
Organic Chemicals > Ketones > Butyrophenones
Amino Acids, Peptides, and Proteins > Peptides > Peptide Hormones
Organic Chemicals > Amides > Benzamides
Hemic and Immune Systems > Blood
ID Code:2758
Deposited By:Dr. Lut Tamam
Deposited On:20 March 2008

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