Short-course chemotherapy of pulmonary tuberculosis: second Tuberculosis Association of India trial

Pamra, S.P.; Viswanathan, R.; Dingley, H.B. and Singh, M.M. (1984) Short-course chemotherapy of pulmonary tuberculosis: second Tuberculosis Association of India trial. Indian Journal of Tuberculosis, 31 (2). pp. 81-88.

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Abstract

Two short course regimens were studied in 175 patients. In one regimen, RMP, INH and P7A were given daily for the initial intensive phase of eight weeks. In the other SM was added during this phase. Patients whose sputum was converted by direct smear at 8 weeks were treated randomly with RMP and INH daily for a further 4 or 18 weeks in both regimens. Patients who continued to have a positive smear at 8 weeks were treated with RMP and INH daily for 18 weeks after the initial intensive phase of 8 weeks. Only 1 patient remained unconverted at the termination of chemotherapy. There was only one bacteriological reversion during at least 18 months of follow up after termination of chemotherapy among those treated for 26 weeks. Nearly one fourth of the patients had bacteriological reversion among those treated for 12 weeks only. All patients who harboured initially drug resistant bacilli were converted if their treatment was for 26 weeks and there was no relapse among these.

EPrint Type:Article
Additional Information:This report was compiled by Dr. S.P. Pamra, Hony. Technical Adviser of the Tuberculosis Association of India on behalf of its Research Committee, which, then, consisted of late Dr. R. Viswanathan, Dr. H.B. Dingley, Dr. M.M. Singh and the author of the report.
Uncontrolled Keywords:Rifampicin, INH, Streptomycin, Short Course Regimens, Short Course Chemotherapy, Ethambutol, Pyrazinamide, Pulmonary Tuberculosis, Tuberculosis Association of India, Trials, Direct Smear
Subjects:Therapeutics > Drug Therapy
Chemical and Pharmacologic Phenomena > Drug Resistance
Organic Chemicals > Hydrazines > Isoniazid
Therapeutics > Combined Modality Therapy
Organic Chemicals > Amines > Polyamines
Heterocyclic Compounds > Heterocyclic Compounds with 4 or More Rings > Rifamycins
Respiratory Tract Diseases > Respiratory Tract Infections > Tuberculosis, Pulmonary
Pharmaceutical Preparations > Drug Combinations
Carbohydrates and Hypoglycemic Agents > Carbohydrates > Glycosides > Aminoglycosides > Streptomycin
Investigative Techniques > Drug Administration Schedule
Heterocyclic Compounds > Heterocyclic Compounds, 1-Ring > Pyrazines
Chemical and Pharmacologic Phenomena > Drug Design
Respiratory Tract Diseases > Lung Diseases > Tuberculosis, Pulmonary
-Journal Repositories > Indian Journal of Tuberculosis
ID Code:2770
Deposited By:Mrs Naina Pandita
Deposited On:26 March 2008

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